Lurie Andrew, Guntupalli Lohitha, Finnigan Nancy A, Ahmed Umair
Internal Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.
Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Clearwater, USA.
Cureus. 2024 Sep 13;16(9):e69330. doi: 10.7759/cureus.69330. eCollection 2024 Sep.
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a rare multisystem autoimmune disease resulting from necrotizing inflammation of small vessels. Genetic predisposition and environmental factors are typically associated with its presentation, though rarely a drug-induced form has been reported. Here, we present a case of a 73-year-old female with a history of hypertension and chronic kidney disease who presented with acute kidney injury secondary to hydralazine-induced ANCA vasculitis. This report aims to highlight the rare association of hydralazine with vasculitis and the importance of pursuing a full initial workup in patients with acute kidney injury.
抗中性粒细胞胞浆抗体（ANCA）相关血管炎是一种罕见的多系统自身免疫性疾病，由小血管的坏死性炎症引起。遗传易感性和环境因素通常与其发病有关，不过药物诱发型虽罕见但也有报道。在此，我们报告一例73岁女性患者，有高血压和慢性肾脏病病史，因肼苯哒嗪诱发的ANCA血管炎继发急性肾损伤前来就诊。本报告旨在强调肼苯哒嗪与血管炎之间罕见的关联，以及对急性肾损伤患者进行全面初始检查的重要性。
