Watts R A, Lane S E, Bentham G, Scott D G
Norfolk and Norwich Hospital, UK.
Arthritis Rheum. 2000 Feb;43(2):414-9. doi: 10.1002/1529-0131(200002)43:2<414::AID-ANR23>3.0.CO;2-0.
To describe the epidemiology of the primary systemic vasculitides (PSV; Wegener's granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis, polyarteritis nodosa) in a well-defined population over a 10-year period.
An inception cohort of patients from the Norwich Health Authority (NHA) who were >15 years of age and had PSV first diagnosed between January 1, 1988 and December 31, 1997 was collected. Incidence rates were adjusted for age and sex to the 1992 population. The prevalence of PSV in this cohort was estimated on December 31, 1997. Patients were classified according to the American College of Rheumatology 1990 vasculitis criteria and the Chapel Hill Consensus definitions.
Eighty-two NHA residents fulfilled the inclusion criteria. There were 47 men and 35 women, with a mean age of 62.9 years (median 65.0 years). The overall annual incidence of PSV among NHA residents was 19.8/million (95% confidence interval [95% CI] 15.8-24.6). The point prevalence on December 31, 1997 was 144.5/million (95% CI 110.4-185.3). PSV was more common in males (23.5/million; 95% CI 17.3-31.3) than females (16.4/million; 95% CI 11.4-22.8). The age- and sex-specific incidence showed a clear increase with age, with an overall peak in the 65-74 year age group (60.1/million).
In our study population, the annual incidence of PSV is slowly increasing with time and the incidence is greatest in the elderly.
描述在一个明确界定的人群中，为期10年的原发性系统性血管炎（PSV；韦格纳肉芽肿、变应性肉芽肿性血管炎、显微镜下多血管炎、结节性多动脉炎）的流行病学情况。
收集诺维奇卫生局（NHA）年龄大于15岁、于1988年1月1日至1997年12月31日首次诊断为PSV的患者起始队列。发病率按年龄和性别调整至1992年的人口数据。在1997年12月31日估计该队列中PSV的患病率。患者根据美国风湿病学会1990年血管炎标准和查珀尔希尔共识定义进行分类。
82名NHA居民符合纳入标准。其中男性47名，女性35名，平均年龄62.9岁（中位数65.0岁）。NHA居民中PSV的总体年发病率为19.8/百万（95%置信区间[95%CI]15.8 - 24.6）。1997年12月31日的时点患病率为144.5/百万（95%CI 110.4 - 185.3）。PSV在男性中（23.5/百万；95%CI 17.3 - 31.3）比女性中（16.4/百万；95%CI 11.4 - 22.8）更常见。年龄和性别特异性发病率随年龄明显增加，在65 - 74岁年龄组总体达到峰值（60.1/百万）。
在我们的研究人群中，PSV的年发病率随时间缓慢增加，且发病率在老年人中最高。
