Tiwari Anant, Khillan Kamini, Poddar Mayank, Ranjan Vivek
Orthopedics, Sir Ganga Ram Hospital, New Delhi, IND.
Pathology, Sir Ganga Ram Hospital, New Delhi, IND.
Cureus. 2024 Sep 12;16(9):e69271. doi: 10.7759/cureus.69271. eCollection 2024 Sep.
Osteonecrosis is characterized by the necrosis of trabecular bone and cells within the femoral head, which often results in the subchondral collapse and deformation of the articulating surface of the head. For the treatment of early stages of this condition, specifically Stage I and Stage II, bone marrow-derived stem cells have been employed effectively for several years. In our approach, we have utilized a modified technique to collect bone marrow aspirate, which has yielded favorable outcomes.
In our study, we performed surgeries on 32 hips afflicted with early-stage osteonecrosis of the femoral head. Each patient underwent core decompression and the injection of bone marrow concentrate, guided by C-arm imaging in the operating theater. Evaluations were conducted using the Harris Hip Score and the Visual Analogue Scale (VAS), along with radiological assessments to track the progression of osteonecrosis stages before and after the surgical procedure.
The comparison of pre- and post-surgery data, including the Harris Hip Score, VAS, progression of osteonecrosis stages, and radiological findings, revealed significantly positive outcomes. Since May 2013, 32 hips, regardless of the etiology of avascular necrosis (AVN), have been treated with this procedure. Notably, only four patients with bilateral AVN progressed to Stage III in one hip, while the other hip remained stable. In the remaining patients, pain was alleviated, and none progressed to later stages. No complications were observed in this study.
This minimally invasive technique, characterized by its simplicity and lack of associated complications or donor site morbidity, has proven to be an effective joint-preserving surgical intervention for early stages of femoral head osteonecrosis (Stages 1 and 2).
骨坏死的特征是股骨头内小梁骨和细胞坏死,常导致软骨下塌陷和股骨头关节面变形。对于这种疾病早期(即I期和II期)的治疗,骨髓来源的干细胞已被有效应用数年。在我们的方法中,我们采用了一种改良技术来采集骨髓抽吸物,取得了良好的效果。
在我们的研究中,我们对32例患有早期股骨头骨坏死的髋关节进行了手术。每位患者在手术室的C形臂成像引导下接受了髓芯减压和骨髓浓缩物注射。使用Harris髋关节评分和视觉模拟量表(VAS)进行评估,并进行放射学评估以跟踪手术前后骨坏死阶段的进展。
手术前后数据的比较,包括Harris髋关节评分、VAS、骨坏死阶段进展和放射学结果,显示出显著的积极结果。自2013年5月以来,32个髋关节,无论无血管坏死(AVN)的病因如何,均采用该手术进行治疗。值得注意的是,只有4例双侧AVN患者的一个髋关节进展到III期,而另一个髋关节保持稳定。在其余患者中,疼痛得到缓解,且无患者进展到后期阶段。本研究中未观察到并发症。
这种微创技术具有操作简单、无相关并发症或供区并发症的特点,已被证明是治疗早期股骨头骨坏死(1期和2期)的一种有效的保关节手术干预方法。