韩国中年成年人食物摄入量与血清芳烃受体配体活性之间的关联。
Association between food consumption and serum aryl hydrocarbon receptor ligand activity among middle-aged Korean adults.
作者信息
Ha Kyungho, Choi Hoonsung, Pak Youngmi Kim, Lee Hong Kyu, Joung Hyojee
机构信息
Department of Food Science and Nutrition, Jeju National University, Jeju 63243, Korea.
Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul 06974, Korea.
出版信息
Nutr Res Pract. 2024 Oct;18(5):711-720. doi: 10.4162/nrp.2024.18.5.711. Epub 2024 Sep 9.
BACKGROUND/OBJECTIVES: The diet is an important route of exposure to endocrine-disrupting chemicals (EDCs). However, few studies have investigated the association between dietary intake and EDC exposure levels among Koreans. In an earlier study, we showed that the bioactivity of serum aryl hydrocarbon receptor ligands (AhRLs) could be a surrogate biomarker to indicate exposure to EDCs and that they inhibit mitochondrial function. We also found that the mitochondria-inhibiting substances (MIS) in serum ascertained by intracellular adenosine triphosphate (MIS-ATP) and reactive oxygen species (MIS-ROS) levels could be biomarkers of exposure to EDCs, as they showed a strong correlation with AhRL and the levels of EDCs in the blood. Here, we investigated the association between the consumption of specific foods and surrogate serum biomarkers for EDCs, namely AhRL, MIS-ATP, and MIS-ROS, among middle-aged Korean adults.
SUBJECTS/METHODS: A total of 1,466 participants aged 45-76 yrs from the Ansung cohort of the Korean Genome and Epidemiology Study were included. Food consumption, including that of meat, fish, vegetables, and fruits, was measured using a semiquantitative food frequency questionnaire.
RESULTS
Fish intake was positively associated with AhRL (β = 0.0035, = 0.0166), whereas cruciferous vegetable intake was negatively associated with AhRL (β = -0.0007, = 0.0488). Cruciferous vegetable intake was positively associated with the MIS-ATP levels (β = 0.0051, = 0.0420). A higher intake of fish was significantly associated with an increased risk of high AhRL (tertile: odds ratio [OR], 1.49; 95% confidence intervals (CIs), 1.08-2.06; for trend = 0.0305). In addition, the second-highest tertile of cruciferous vegetable intake had lower odds of high AhRL than the lowest tertile (OR, 0.73; 95% CIs, 0.54-0.97), although no significant linear trend was observed.
CONCLUSION
Consumption of different types of foods may be differentially associated with EDC exposure in middle-aged Korean adults.
背景/目的：饮食是接触内分泌干扰化学物质（EDC）的重要途径。然而，很少有研究调查韩国人饮食摄入量与EDC暴露水平之间的关联。在一项早期研究中，我们表明血清芳烃受体配体（AhRL）的生物活性可能是指示EDC暴露的替代生物标志物，并且它们会抑制线粒体功能。我们还发现，通过细胞内三磷酸腺苷（MIS-ATP）和活性氧（MIS-ROS）水平确定的血清中线粒体抑制物质（MIS）可能是EDC暴露的生物标志物，因为它们与AhRL以及血液中EDC的水平显示出很强的相关性。在此，我们调查了韩国中年成年人中特定食物的消费与EDC的替代血清生物标志物（即AhRL、MIS-ATP和MIS-ROS）之间的关联。
对象/方法：纳入了韩国基因组与流行病学研究安城队列中1466名年龄在45 - 76岁的参与者。使用半定量食物频率问卷测量食物摄入量，包括肉类、鱼类、蔬菜和水果的摄入量。
结果
鱼类摄入量与AhRL呈正相关（β = 0.0035，P = 0.0166），而十字花科蔬菜摄入量与AhRL呈负相关（β = -0.0007，P = 0.0488）。十字花科蔬菜摄入量与MIS-ATP水平呈正相关（β = 0.0051，P = 0.0420）。鱼类摄入量较高与AhRL升高风险显著相关（三分位数：优势比[OR]，1.49；95%置信区间（CI），1.08 - 2.06；趋势检验P = 0.0305）。此外，十字花科蔬菜摄入量第二高的三分位数与最低三分位数相比，AhRL升高的几率较低（OR，0.73；95% CI，0.54 - 0.97），尽管未观察到显著的线性趋势。
结论
不同类型食物的消费可能与韩国中年成年人的EDC暴露存在不同关联。
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