Itsukage Shizu, Kume Noriko, Tajima Aki, Okazaki Takashi, Tsuta Koji, Tanizaki Hideaki
Department of Dermatology, Kansai Medical University Hospital, 2-5-1 Shinmachi, Hirakata City, Osaka Japan.
Third Department of Internal Medicine, Kansai Medical University Hospital, Hirakata City, Japan.
Int Cancer Conf J. 2024 Sep 18;13(4):454-459. doi: 10.1007/s13691-024-00709-y. eCollection 2024 Oct.
Immune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in various organs. Herein, we present a rare case involving a patient with immunotherapy-related gastritis who developed refractory vomiting and anorexia after treatment with nivolumab for cutaneous malignant melanoma. The patient was treated with oral corticosteroids, but the efficacy was limited. The symptoms improved markedly after treatment with infliximab. With the increasing use of ICIs, the number of reports of gastritis due to irAEs has also increased. Health care providers treating malignancies should be aware of this side effect and know how to diagnose and treat it.
免疫检查点抑制剂（ICIs）可在各个器官引发免疫相关不良事件（irAEs）。在此，我们报告一例罕见病例，一名接受免疫治疗相关胃炎的患者，在用纳武单抗治疗皮肤恶性黑色素瘤后出现难治性呕吐和厌食。患者接受了口服糖皮质激素治疗，但疗效有限。使用英夫利昔单抗治疗后症状明显改善。随着ICIs使用的增加，因irAEs导致胃炎的报告数量也有所增加。治疗恶性肿瘤的医护人员应意识到这种副作用，并知道如何诊断和治疗。
