Kishimoto Y, Akanuma H, Singh I
Mol Cell Biochem. 1979 Dec 14;28(1-3):93-105. doi: 10.1007/BF00223361.
alpha-Hydroxylation is an enzymatic reaction by which long-chain fatty acids are converted to their alpha-hydroxy derivatives. This reaction, in animals, can be detected only in developing brain and is the rate-determining step in the synthesis of hydroxycerebroside, which is an indispensable and abundant myelin lipid. In addition to a particulate fraction from brain, two cytoplasmic factors, one heat-stable and the other heat-labile, are required for alpha-hydroxylation. During the past eight years we have been investigating alpha-hydroxylation. Our progress is summarized and discussed here.
α-羟化是一种酶促反应，通过该反应长链脂肪酸被转化为其α-羟基衍生物。在动物体内，这种反应仅在发育中的大脑中可检测到，并且是羟基脑苷脂合成中的限速步骤，羟基脑苷脂是一种不可或缺且含量丰富的髓磷脂脂质。除了来自大脑的微粒体部分外，α-羟化还需要两种细胞质因子，一种是热稳定的，另一种是热不稳定的。在过去八年中，我们一直在研究α-羟化。我们的进展在此进行总结和讨论。
