Berke G
Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Microbiol Sci. 1985;2(2):44-6, 51-2.
Cytolytic T lymphocytes (CTL) are primary immune effector cells involved in allograft rejection, virus infection and, possibly, tumour immunity. This article is concerned primarily with their in vivo functions and with the mechanism whereby they bind to, and kill, target cells in vitro. A working hypothesis viewing CTL-mediated target cell lysis as the end result of CTL-induced stimulatory exhaustion of the target cell is discussed.
细胞溶解性T淋巴细胞（CTL）是参与同种异体移植排斥反应、病毒感染以及可能的肿瘤免疫的主要免疫效应细胞。本文主要关注它们在体内的功能以及它们在体外结合并杀死靶细胞的机制。文中讨论了一个工作假说，该假说将CTL介导的靶细胞裂解视为CTL诱导的靶细胞刺激性耗竭的最终结果。
