Department of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, Zhejiang, China.
Department of Clinical Laboratory, Beidahuang Industry Group General Hospital, Harbin, Heilongjiang, China.
Microbiol Spectr. 2024 Nov 5;12(11):e0135024. doi: 10.1128/spectrum.01350-24. Epub 2024 Oct 14.
can cause invasive diseases, including bloodstream infections. However, existing research primarily focuses on specific populations, and limited studies have been conducted on the prevalence of bloodstream infection caused by across the entire pediatric population. Therefore, clinical data of isolated from blood samples at Children's Hospital, Zhejiang University School of Medicine, during the period 2019-2023 were collected retrospectively to provide a comprehensive understanding of the clinical characteristics and drug resistance patterns associated with bloodstream infections caused by in pediatric populations. There were 57 (43.5%) instances of contamination across various departments, indicating a relatively dispersed pattern. Bloodstream infections caused by are notably prevalent among pediatric patients with hematological diseases and tumors. The susceptibility rates of the 74 isolates to different antibiotics were as follows: penicillin (23%), ceftriaxone (74.3%), levofloxacin (86.5%), chloramphenicol (89.2%), erythromycin (27%), clindamycin (67.6%), linezolid (100%), and vancomycin (100%). Notably, 21.6% of the isolates exhibited multi-drug resistance (MDR). The predominant mode of MDR in infections was identified as resistance to β-lactams, erythromycin, and clindamycin. The observed low susceptibility rate to penicillin, coupled with the emergence of MDR strains, underscores the imperative for continuous monitoring of the evolving antimicrobial resistance in .
Existing research primarily focuses on specific populations, such as those with hematopathy or tumors, who experience bacteremia. Limited studies have been conducted on the prevalence of bloodstream infections caused by across the entire pediatric population. It was found that the contamination rate of isolated from blood cultures was notably high in our study. Therefore, this study evaluated the clinical characteristics and drug resistance patterns of bloodstream infections caused by across the entire pediatric populations, explicitly excluding cases of blood culture contamination. The observed low susceptibility rate to penicillin, coupled with the emergence of multi-drug-resistant strains, underscores the imperative for continuous monitoring of the evolving antimicrobial resistance in .
目前的研究主要集中在特定人群，如血液系统疾病或肿瘤患者，这些患者易发生菌血症。针对儿科人群中由 引起的血流感染的患病率，仅有有限的研究。本研究发现，从血培养中分离出的 污染率明显较高。因此，本研究评估了整个儿科人群中由 引起的血流感染的临床特征和耐药模式，明确排除了血培养污染的病例。青霉素的低敏感性，加上多药耐药菌株的出现，突显了不断监测 中抗菌药物耐药性演变的必要性。
