和 突变与 和 中的达托霉素耐药性相关。
Mutations in and Correlate with Daptomycin Resistance in and .
机构信息
Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, Texas, USA.
LA Biomedical Research Institute, Torrance, California, USA.
出版信息
Antimicrob Agents Chemother. 2019 Jan 29;63(2). doi: 10.1128/AAC.01531-18. Print 2019 Feb.
Abstract
We investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (/ subgroup) from daptomycin (DAP)-naive patients to develop DAP resistance All strains rapidly developed high-level and stable DAP resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified, i.e., CdsA (phosphatidate cytidylyltransferase) and PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3-phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. DAP interactions with the cell membrane differed in isolates with PgsA versus CdsA substitutions.
摘要
我们研究了来自达托霉素（DAP）初治患者的几种近期临床草绿色链球菌（VGS）血流分离株（/亚群）获得 DAP 耐药性的能力。所有菌株均迅速产生高水平且稳定的 DAP 耐药性。鉴定出两种参与心磷脂生物合成途径的酶的突变，即 CdsA（磷酸甘油酸胞苷二酯转移酶）和 PgsA（CDP-二酰基甘油-甘油-3-磷酸-3-磷脂酰转移酶）。这些突变与细胞膜中磷脂酰甘油和心磷脂的完全消失有关。DAP 与细胞膜的相互作用在 PgsA 与 CdsA 取代的分离株中有所不同。
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