• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Mutations in and Correlate with Daptomycin Resistance in and .和 突变与 和 中的达托霉素耐药性相关。
Antimicrob Agents Chemother. 2019 Jan 29;63(2). doi: 10.1128/AAC.01531-18. Print 2019 Feb.
2
Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria.缓症链球菌和口腔链球菌对CdsA没有需求，CdsA是细菌中主要膜磷脂合成所需的酶。
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02552-16. Print 2017 May.
3
Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism.磷脂酸胞苷转移酶（CdsA）的扰动通过一种新机制介导缓症链球菌/口腔链球菌对达托霉素的耐药性。
Antimicrob Agents Chemother. 2017 Mar 24;61(4). doi: 10.1128/AAC.02435-16. Print 2017 Apr.
4
Daptomycin Dose-Ranging Evaluation with Single-Dose versus Multidose Ceftriaxone Combinations against Streptococcus mitis in an Simulated Endocarditis Vegetation Model.达托霉素单剂量与头孢曲松多剂量联合治疗草绿色链球菌心内膜炎模拟赘生物模型的剂量范围评价。
Antimicrob Agents Chemother. 2019 May 24;63(6). doi: 10.1128/AAC.00386-19. Print 2019 Jun.
5
Metabolic changes associated with adaptive resistance to daptomycin in Streptococcus mitis-oralis.与屎肠球菌-口腔链球菌对达托霉素适应性耐药相关的代谢变化。
BMC Microbiol. 2020 Jun 15;20(1):162. doi: 10.1186/s12866-020-01849-w.
6
Prevention of High-Level Daptomycin-Resistance Emergence In Vitro in Streptococcus mitis-oralis by Using Combination Antimicrobial Strategies.通过联合抗菌策略预防口腔缓症链球菌体外高水平达托霉素耐药性的出现
Curr Microbiol. 2018 Aug;75(8):1062-1067. doi: 10.1007/s00284-018-1491-3. Epub 2018 Apr 12.
7
Strain-Specific Adaptations of to Serial In Vitro Passage in Daptomycin (DAP): Genotypic and Phenotypic Characteristics.达托霉素（DAP）中菌株对连续体外传代的特异性适应性：基因型和表型特征
Antibiotics (Basel). 2020 Aug 15;9(8):520. doi: 10.3390/antibiotics9080520.
8
Combinations of Daptomycin plus Ceftriaxone, but Not Ascending Daptomycin Dose-Regimens, Are Effective in Experimental Endocarditis Caused by Streptococcus mitis Strains: Target Tissue Clearances and Prevention of Emergence of Daptomycin-Resistance.达托霉素联合头孢曲松有效，而不是递增达托霉素剂量方案，对草绿色链球菌引起的实验性心内膜炎有效：靶向组织清除率和预防达托霉素耐药性的出现。
Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0147222. doi: 10.1128/aac.01472-22. Epub 2023 Mar 6.
9
Early in vitro and in vivo development of high-level daptomycin resistance is common in mitis group Streptococci after exposure to daptomycin.米氏链球菌在接触达托霉素后，其高水平达托霉素耐药性的早期体外和体内发展是常见的。
Antimicrob Agents Chemother. 2013 May;57(5):2319-25. doi: 10.1128/AAC.01921-12. Epub 2013 Mar 11.
10
Impact of High-Level Daptomycin Resistance in the Streptococcus mitis Group on Virulence and Survivability during Daptomycin Treatment in Experimental Infective Endocarditis.缓症链球菌群中高水平达托霉素耐药性对实验性感染性心内膜炎达托霉素治疗期间毒力和生存能力的影响
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02418-16. Print 2017 May.

引用本文的文献

1
Pan-genome analysis of serotype 2 highlights genes associated with virulence and antibiotic resistance.2型血清型的泛基因组分析揭示了与毒力和抗生素耐药性相关的基因。
Front Microbiol. 2024 Feb 21;15:1362316. doi: 10.3389/fmicb.2024.1362316. eCollection 2024.
2
Membrane Phenotypic, Metabolic and Genotypic Adaptations of Strains Destined to Rapidly Develop Stable, High-Level Daptomycin Resistance during Daptomycin Exposures.在达托霉素暴露期间，菌株为快速产生稳定的高水平达托霉素耐药性而发生的膜表型、代谢和基因型适应性变化。
Antibiotics (Basel). 2023 Jun 21;12(7):1083. doi: 10.3390/antibiotics12071083.
3
Comparison of Phenotype and Genotype Virulence and Antimicrobial Factors of Typhimurium Isolated from Human Milk.人乳中分离的鼠伤寒沙门氏菌的表型和基因型毒力及抗菌因子比较。
Int J Mol Sci. 2023 Mar 7;24(6):5135. doi: 10.3390/ijms24065135.
4
Bacterial cell membranes and their role in daptomycin resistance: A review.细菌细胞膜及其在达托霉素耐药性中的作用：综述
Front Mol Biosci. 2022 Nov 14;9:1035574. doi: 10.3389/fmolb.2022.1035574. eCollection 2022.
5
The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface.磷脂酰甘油磷酸合酶PgsA在膜 - 胞质溶胶界面利用三叉状两亲性腔进行催化。
Curr Res Struct Biol. 2021 Nov 23;3:312-323. doi: 10.1016/j.crstbi.2021.11.005. eCollection 2021.
6
Whole-genome sequencing reveals high genetic diversity of Streptococcus uberis isolated from cows with mastitis.全基因组测序揭示了乳腺炎奶牛源停乳链球菌的高遗传多样性。
BMC Vet Res. 2021 Oct 7;17(1):321. doi: 10.1186/s12917-021-03031-4.
7
Comparative proteomic investigation of multiple methicillin-resistant strains generated through adaptive laboratory evolution.通过适应性实验室进化产生的多种耐甲氧西林菌株的比较蛋白质组学研究。
iScience. 2021 Aug 6;24(9):102950. doi: 10.1016/j.isci.2021.102950. eCollection 2021 Sep 24.
8
Binding Studies Reveal Phospholipid Specificity and Its Role in the Calcium-Dependent Mechanism of Action of Daptomycin.结合研究揭示了达托霉素与磷脂的特异性结合及其在依赖钙的作用机制中的作用。
ACS Infect Dis. 2021 Sep 10;7(9):2612-2619. doi: 10.1021/acsinfecdis.1c00316. Epub 2021 Aug 18.
9
Development of High-Level Daptomycin Resistance in and Species Isolates from Patients with Infective Endocarditis.患者感染性心内膜炎中 及 种属分离株高水平达托霉素耐药的产生。
Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0252220. doi: 10.1128/AAC.02522-20. Epub 2021 Jul 12.
10
Mechanistic Fingerprinting Reveals Kinetic Signatures of Resistance to Daptomycin and Host Defense Peptides in .机制指纹图谱揭示了对达托霉素和宿主防御肽耐药的动力学特征。
Antibiotics (Basel). 2021 Apr 8;10(4):404. doi: 10.3390/antibiotics10040404.

本文引用的文献

1
Mechanism of High-Level Daptomycin Resistance in .高产万古霉素耐药性机制在. 中的研究。
mSphere. 2018 Aug 8;3(4):e00371-18. doi: 10.1128/mSphereDirect.00371-18.
2
Impact of High-Level Daptomycin Resistance in the Streptococcus mitis Group on Virulence and Survivability during Daptomycin Treatment in Experimental Infective Endocarditis.缓症链球菌群中高水平达托霉素耐药性对实验性感染性心内膜炎达托霉素治疗期间毒力和生存能力的影响
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02418-16. Print 2017 May.
3
Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria.缓症链球菌和口腔链球菌对CdsA没有需求，CdsA是细菌中主要膜磷脂合成所需的酶。
Antimicrob Agents Chemother. 2017 Apr 24;61(5). doi: 10.1128/AAC.02552-16. Print 2017 May.
4
Perturbations of Phosphatidate Cytidylyltransferase (CdsA) Mediate Daptomycin Resistance in Streptococcus mitis/oralis by a Novel Mechanism.磷脂酸胞苷转移酶（CdsA）的扰动通过一种新机制介导缓症链球菌/口腔链球菌对达托霉素的耐药性。
Antimicrob Agents Chemother. 2017 Mar 24;61(4). doi: 10.1128/AAC.02435-16. Print 2017 Apr.
5
In Vivo and in Vitro Synthesis of Phosphatidylglycerol by an Escherichia coli Cardiolipin Synthase.大肠杆菌心磷脂合酶在体内和体外合成磷脂酰甘油
J Biol Chem. 2016 Nov 25;291(48):25144-25153. doi: 10.1074/jbc.M116.762070. Epub 2016 Oct 19.
6
Bacterial membrane lipids: diversity in structures and pathways.细菌膜脂：结构与途径的多样性。
FEMS Microbiol Rev. 2016 Jan;40(1):133-59. doi: 10.1093/femsre/fuv008. Epub 2015 Apr 9.
7
Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis.磷脂生物合成关键的膜内脂核苷酸合成酶的结构与机制
Nat Commun. 2014 Jun 27;5:4244. doi: 10.1038/ncomms5244.
8
Structural basis for catalysis in a CDP-alcohol phosphotransferase.CDP-醇磷酸转移酶催化作用的结构基础
Nat Commun. 2014 Jun 13;5:4068. doi: 10.1038/ncomms5068.
9
Early in vitro and in vivo development of high-level daptomycin resistance is common in mitis group Streptococci after exposure to daptomycin.米氏链球菌在接触达托霉素后，其高水平达托霉素耐药性的早期体外和体内发展是常见的。
Antimicrob Agents Chemother. 2013 May;57(5):2319-25. doi: 10.1128/AAC.01921-12. Epub 2013 Mar 11.
10
Cardiolipin biosynthesis in Streptococcus mutans is regulated in response to external pH.变形链球菌中心脂双层生物合成对外界 pH 有响应性调节。
Microbiology (Reading). 2012 Aug;158(Pt 8):2133-2143. doi: 10.1099/mic.0.057273-0. Epub 2012 May 24.

和 突变与 和 中的达托霉素耐药性相关。

Mutations in and Correlate with Daptomycin Resistance in and .

机构信息

Center for Antimicrobial Resistance and Microbial Genomics and Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, Texas, USA.

LA Biomedical Research Institute, Torrance, California, USA.

出版信息

Antimicrob Agents Chemother. 2019 Jan 29;63(2). doi: 10.1128/AAC.01531-18. Print 2019 Feb.

DOI:10.1128/AAC.01531-18
PMID:30509945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6355606/
Abstract

We investigated the ability of several recent clinical viridans group streptococci (VGS) bloodstream isolates (/ subgroup) from daptomycin (DAP)-naive patients to develop DAP resistance All strains rapidly developed high-level and stable DAP resistance. Substitutions in two enzymes involved in the cardiolipin biosynthesis pathway were identified, i.e., CdsA (phosphatidate cytidylyltransferase) and PgsA (CDP-diacylglycerol-glycerol-3-phosphate-3-phosphatidyltransferase). These mutations were associated with complete disappearance of phosphatidylglycerol and cardiolipin from cell membranes. DAP interactions with the cell membrane differed in isolates with PgsA versus CdsA substitutions.

摘要

我们研究了来自达托霉素（DAP）初治患者的几种近期临床草绿色链球菌（VGS）血流分离株（/亚群）获得 DAP 耐药性的能力。所有菌株均迅速产生高水平且稳定的 DAP 耐药性。鉴定出两种参与心磷脂生物合成途径的酶的突变，即 CdsA（磷酸甘油酸胞苷二酯转移酶）和 PgsA（CDP-二酰基甘油-甘油-3-磷酸-3-磷脂酰转移酶）。这些突变与细胞膜中磷脂酰甘油和心磷脂的完全消失有关。DAP 与细胞膜的相互作用在 PgsA 与 CdsA 取代的分离株中有所不同。