Arshad Mahnaz, Mazidi Yekta, Chiniforush Nasim, Shirvani Armin, Bassir Seyed Hossein
Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Department of Prosthodontics, School of Dentistry, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Photochem Photobiol. 2025 May-Jun;101(3):709-727. doi: 10.1111/php.14033. Epub 2024 Oct 14.
This study was designed to determine the effect of photobiomodulation therapy on dental implant stability. A complete systematic search was performed in PUBMED/MEDLINE, COCHRANE library databases, EMBASE, SCOPUS, and Google Scholar databases on articles published until June 2024. All the RCTs and CCTs reported the solo impact of photobiomodulation on dental implant stability in humans were included. The means and standard deviation for implant stability and sample size were extracted for the meta-analysis. The statistical analysis was conducted using Stata 17 software, and random effect models were applied to assess the source of heterogeneity. The I2 statistic was used to estimate the significance of any discrepancies in the therapy result. After a full-text inspection, 17 articles were qualified for systematic review, and 14 were included in the meta-analysis. Statically significant differences in implant stability were observed between the laser and the control groups on weeks 2 in ISQ reporting groups (p = 0.01, CI 95%) and weeks 4 and 8 in PTV reporting groups (p < 0.001, CI 95%). Despite limitations, the study suggests that PBM therapy benefits patients with dental implants at different periods, particularly during the early phases of healing.
本研究旨在确定光生物调节疗法对牙种植体稳定性的影响。在PUBMED/MEDLINE、COCHRANE图书馆数据库、EMBASE、SCOPUS和谷歌学术数据库中对截至2024年6月发表的文章进行了全面的系统检索。纳入了所有报告光生物调节对人类牙种植体稳定性单独影响的随机对照试验（RCT）和临床对照试验（CCT）。提取种植体稳定性的均值、标准差和样本量用于荟萃分析。使用Stata 17软件进行统计分析，并应用随机效应模型评估异质性来源。I2统计量用于估计治疗结果中任何差异的显著性。经过全文审查，17篇文章符合系统评价的条件，14篇纳入荟萃分析。在ISQ报告组的第2周（p = 0.01，95%置信区间）以及PTV报告组的第4周和第8周（p < 0.001，95%置信区间），激光组和对照组之间在种植体稳定性方面观察到统计学上的显著差异。尽管存在局限性，但该研究表明，光生物调节疗法在不同时期对牙种植体患者有益，尤其是在愈合早期。
