Department of Central Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
J Neurosci Res. 2024 Oct;102(10):e25391. doi: 10.1002/jnr.25391.
As an important subtype of GABAergic interneurons, parvalbumin (PV) interneurons play a critical role in regulating cortical circuits and neural networks. Abnormalities in the development or function of PV interneurons have been linked to autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by social and language deficits. In this review, we focus on the abnormalities of PV interneurons in ASD, including quantity and function and discuss the underlying mechanisms of impairments in PV interneurons in the pathology of ASD. Finally, we propose potential therapeutic approaches targeting PV interneurons, such as transplanting MGE progenitor cells and utilizing optogenetic stimulation in the treatment of ASD.
作为 GABA 能中间神经元的重要亚型，小脑浦肯野细胞（PV）中间神经元在调节皮质回路和神经网络方面发挥着关键作用。PV 中间神经元的发育或功能异常与自闭症谱系障碍（ASD）有关，ASD 是一种以社交和语言缺陷为特征的神经发育障碍。在这篇综述中，我们重点关注 ASD 中 PV 中间神经元的异常，包括数量和功能，并讨论了在 ASD 病理中 PV 中间神经元损伤的潜在机制。最后，我们提出了针对 PV 中间神经元的潜在治疗方法，例如移植 MGE 祖细胞和利用光遗传学刺激治疗 ASD。
