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迈向生物同手性的一步步——从益生元的随机性到完美不对称性

Step-by-Step Towards Biological Homochirality - from Prebiotic Randomness To Perfect Asymmetry.

作者信息

Mejdrová Ivana, Węgrzyn Ewa, Carell Thomas

机构信息

Department of Chemistry, Institute for Chemical Epigenetics (ICE-M), Ludwig-Maximilians-Universität (LMU) München, Butenandtstrasse 5-13, 81377, Munich, Germany.

出版信息

Chem Asian J. 2025 Jan 2;20(1):e202401074. doi: 10.1002/asia.202401074. Epub 2024 Nov 19.

Abstract

The history of life's formation and the origin of its stereochemistry are nearly as multifaceted as the life itself. In this review, we focus on analyzing the step-by-step path leading to what we can define as "life" in parallel to what we know about the emergence of enantiomeric imbalance and subsequent transition to full homochirality. We start at the level of assembly of the building blocks of life from inorganic molecules and build up to the polymerization and formation of nucleic acids and peptides. We report and analyze different theories at various stages of this development and try to elucidate the most plausible theory.

摘要

生命形成的历史及其立体化学的起源几乎与生命本身一样具有多面性。在本综述中,我们着重分析逐步通向我们可定义为“生命”的过程,同时结合我们对对映体失衡的出现以及随后向完全同手性转变的了解。我们从无机分子组装生命基本组成部分的层面开始,逐步深入到核酸和肽的聚合与形成。我们报告并分析这一发展过程各个阶段的不同理论,并试图阐明最合理的理论。

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