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人工智能在体外受精中的应用综述。

A review of artificial intelligence applications in in vitro fertilization.

作者信息

Zhang Qing, Liang Xiaowen, Chen Zhiyi

机构信息

Key Laboratory of Medical Imaging Precision Theranostics and Radiation Protection, College of Hunan Province, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China.

Institute of Medical Imaging, Hengyang Medical School, University of South China, Hengyang, China.

出版信息

J Assist Reprod Genet. 2025 Jan;42(1):3-14. doi: 10.1007/s10815-024-03284-6. Epub 2024 Oct 14.

DOI:10.1007/s10815-024-03284-6
PMID:39400647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11806189/
Abstract

The field of reproductive medicine has witnessed rapid advancements in artificial intelligence (AI) methods, which have significantly enhanced the efficiency of diagnosing and treating reproductive disorders. The integration of AI algorithms into the in vitro fertilization (IVF) has the potential to represent the next frontier in advancing personalized reproductive medicine and enhancing fertility outcomes for patients. The potential of AI lies in its ability to bring about a new era characterized by standardization, automation, and an improved success rate in IVF. At present, the utilization of AI in clinical practice is still in its early stages and faces numerous ethical, regulatory, and technical challenges that require attention. In this review, we present an overview of the latest advancements in various applications of AI in IVF, including follicular monitoring, oocyte assessment, embryo selection, and pregnancy outcome prediction. The aim is to reveal the current state of AI applications in the field of IVF, their limitations, and prospects for future development. Further studies, which involve the development of comprehensive models encompassing multiple functions and the conduct of large-scale randomized controlled trials, could potentially indicate the future direction of AI advancements in the field of IVF.

摘要

生殖医学领域见证了人工智能(AI)方法的迅速发展,这些方法显著提高了生殖疾病的诊断和治疗效率。将人工智能算法整合到体外受精(IVF)中,有可能成为推进个性化生殖医学和提高患者生育成功率的下一个前沿领域。人工智能的潜力在于它能够带来一个以标准化、自动化和提高体外受精成功率为特征的新时代。目前,人工智能在临床实践中的应用仍处于早期阶段,面临着众多需要关注的伦理、监管和技术挑战。在这篇综述中,我们概述了人工智能在体外受精各种应用中的最新进展,包括卵泡监测、卵母细胞评估、胚胎选择和妊娠结局预测。目的是揭示人工智能在体外受精领域的应用现状、局限性以及未来发展前景。进一步的研究,包括开发涵盖多种功能的综合模型和进行大规模随机对照试验,可能会指明人工智能在体外受精领域的未来发展方向。

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1
A review of artificial intelligence applications in in vitro fertilization.人工智能在体外受精中的应用综述。
J Assist Reprod Genet. 2025 Jan;42(1):3-14. doi: 10.1007/s10815-024-03284-6. Epub 2024 Oct 14.
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引用本文的文献

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FERTILITY CARE IN LOW- AND MIDDLE- INCOME COUNTRIES: The future use of AI to improve accessibility of assisted reproductive technology in low- and middle-income countries.低收入和中等收入国家的生育护理:人工智能在低收入和中等收入国家未来用于提高辅助生殖技术可及性的情况。
Reprod Fertil. 2025 Aug 14;6(3). doi: 10.1530/RAF-24-0077. Print 2025 Jul 1.
2
Assisted Reproductive Technology: A Ray of Hope for Infertility.辅助生殖技术:不孕症患者的一线希望。
ACS Omega. 2025 May 23;10(22):22347-22365. doi: 10.1021/acsomega.5c01643. eCollection 2025 Jun 10.
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Obstetrics and Gynecology Medicine: Go from Bench to Bedside.妇产医学:从实验室到临床应用
Life (Basel). 2025 Feb 5;15(2):233. doi: 10.3390/life15020233.

本文引用的文献

1
Clinical outcomes of single blastocyst transfer with machine learning guided noninvasive chromosome screening grading system in infertile patients.机器学习指导的非侵入性染色体筛查分级系统用于不孕患者的单囊胚移植的临床结局。
Reprod Biol Endocrinol. 2024 May 23;22(1):61. doi: 10.1186/s12958-024-01231-9.
2
Enhancing clinical utility: deep learning-based embryo scoring model for non-invasive aneuploidy prediction.提高临床实用性:基于深度学习的胚胎评分模型用于非侵入性的染色体非整倍体预测。
Reprod Biol Endocrinol. 2024 May 22;22(1):58. doi: 10.1186/s12958-024-01230-w.
3
Ex ovo omnia-why don't we know more about egg quality via imaging?从卵中诞生一切——为什么我们不能通过影像学更多地了解卵子质量?
Biol Reprod. 2024 Jun 12;110(6):1201-1212. doi: 10.1093/biolre/ioae080.
4
An artificial intelligence tool predicts blastocyst development from static images of fresh mature oocytes.一种人工智能工具可根据新鲜成熟卵母细胞的静态图像预测囊胚发育情况。
Reprod Biomed Online. 2024 Jun;48(6):103842. doi: 10.1016/j.rbmo.2024.103842. Epub 2024 Jan 18.
5
A novel machine-learning framework based on early embryo morphokinetics identifies a feature signature associated with blastocyst development.一种基于早期胚胎形态动力学的新型机器学习框架,确定了与囊胚发育相关的特征特征。
J Ovarian Res. 2024 Mar 15;17(1):63. doi: 10.1186/s13048-024-01376-6.
6
When the Embryo Meets the Endometrium: Identifying the Features Required for Successful Embryo Implantation.当胚胎遇见子宫内膜:鉴定胚胎着床成功所需的特征。
Int J Mol Sci. 2024 Feb 29;25(5):2834. doi: 10.3390/ijms25052834.
7
The prospect of artificial intelligence to personalize assisted reproductive technology.人工智能实现辅助生殖技术个性化的前景。
NPJ Digit Med. 2024 Mar 1;7(1):55. doi: 10.1038/s41746-024-01006-x.
8
To transfer or not to transfer: the dilemma of mosaic embryos - a narrative review.是否转移:镶嵌胚胎的困境——叙事性综述。
Reprod Biomed Online. 2024 Mar;48(3):103664. doi: 10.1016/j.rbmo.2023.103664. Epub 2023 Nov 2.
9
Associations between the artificial intelligence scoring system and live birth outcomes in preimplantation genetic testing for aneuploidy cycles.人工智能评分系统与胚胎植入前遗传学检测非整倍体周期中活产结局的相关性。
Reprod Biol Endocrinol. 2024 Jan 17;22(1):12. doi: 10.1186/s12958-024-01185-y.
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Artificial intelligence in skeletal metastasis imaging.人工智能在骨转移瘤成像中的应用
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