Sondergaard K, Schou G
Department of Pathology, Finsen Institute, Rigshospitalet, Copenhagen, Denmark.
Am J Dermatopathol. 1985;7 Suppl:1-4. doi: 10.1097/00000372-198501001-00004.
Cox's multivariate regression model for survival data was applied to facts in cases of 2,012 patients with primary cutaneous malignant melanomas in order to evaluate the relative prognostic value of numerous clinicohistologic variables and to establish their prognostically most meaningful combination. The variables that were found to be independent risk factors were clinical stage, site of lesion, thickness of lesion, level of invasion, mitotic figures, ulceration, lymphocytic infiltrate, predominant type of neoplastic cell, and regression. The factors that were found to be without prognostic significance were histological type, nuclear pleomorphism, nucleolar size, vascular invasion, pigmentation, and attendant solar elastosis. The prognostic effects of sex and age of patients were uncertain, and both variables therefore were retained in the model.
将考克斯生存数据多变量回归模型应用于2012例原发性皮肤恶性黑色素瘤患者的病例资料，以评估众多临床组织学变量的相对预后价值，并确定其在预后方面最具意义的组合。发现为独立危险因素的变量有临床分期、病变部位、病变厚度、浸润深度、核分裂象、溃疡形成、淋巴细胞浸润、肿瘤细胞的主要类型及消退情况。发现无预后意义的因素有组织学类型、核多形性、核仁大小、血管浸润、色素沉着及伴发的日光性弹力组织变性。患者性别和年龄的预后影响尚不确定，因此这两个变量均保留在模型中。
