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英国老龄化纵向研究中衰弱与生活质量之间的双向关联

Bidirectional association between frailty and quality of life within English longitudinal study of aging.

作者信息

Alattas Ali, Shuweihdi Farag, Best Kate, Nikolova Silviya, West Robert

机构信息

Leeds Institute of Health Sciences, Faculty of Medicine and Health, University of Leeds, Leeds, UK.

Basic Science Department, College of Science and Health Professions, King Saud bin Abdulaziz for Health Sciences, Jeddah, Saudi Arabia.

出版信息

Qual Life Res. 2025 Jan;34(1):261-271. doi: 10.1007/s11136-024-03809-7. Epub 2024 Oct 14.

Abstract

PURPOSE

The relationship between quality of life (QoL) and frailty has previously been investigated cross-sectionally and longitudinally as unidirectional where QoL depends upon frailty and where frailty depends on QoL. Here a bidirectional relationship is examined.

METHODS

This work uses a latent curve model with structured residuals to address the bidirectional association between QoL and frailty in older English people considering within-person and group levels. The study measures frailty using a functional frailty measure and quality of life using CASP-12. The sample size is 17,529.

RESULTS

There is a strong relationship between QoL (Quality of Life) and frailty, which is almost linear and inversely proportional over time. Although the cross-lagged coefficients from QoL to frailty and vice versa showed statistical significance, the impact was found to be minimal. The time between assessments (which are two years apart) and/or the few observations available per individual may have impacted the effect of this relationship. When accounting for gender, age, net wealth, and multimorbidity, some variations in the results were observed at the group level but not at the within-person level.

CONCLUSION

The study provides empirical evidence that supports a bidirectional association between QoL and frailty in older individuals who reside at home. These results offer valuable insights for healthcare providers, as participants did not exhibit an advanced need for health services. Additionally, involving participants in evaluating and assessing these services enhances their effectiveness and overall benefit.

摘要

目的

此前已对生活质量(QoL)与衰弱之间的关系进行了横断面和纵向研究,研究方向为单向,即生活质量取决于衰弱,以及衰弱取决于生活质量。本文将研究一种双向关系。

方法

本研究使用带有结构化残差的潜在曲线模型,以探讨居家英国老年人生活质量与衰弱之间的双向关联,同时考虑个体内部和群体层面的因素。研究采用功能性衰弱测量方法来衡量衰弱程度,使用CASP-12量表来衡量生活质量。样本量为17529。

结果

生活质量(QoL)与衰弱之间存在很强的关系,这种关系在时间上几乎呈线性且成反比。尽管从生活质量到衰弱以及从衰弱到生活质量的交叉滞后系数具有统计学意义,但发现其影响极小。评估之间的时间间隔(相隔两年)和/或每个个体可用的观测数据较少,可能影响了这种关系的效果。在考虑性别、年龄、净财富和多种疾病时,在群体层面观察到了结果的一些差异,但在个体内部层面未观察到差异。

结论

该研究提供了实证证据,支持居家老年人生活质量与衰弱之间的双向关联。这些结果为医疗保健提供者提供了有价值的见解,因为参与者并未表现出对健康服务的迫切需求。此外,让参与者参与评估这些服务可提高其有效性和整体效益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d0df/11802669/86b85fbff256/11136_2024_3809_Fig1_HTML.jpg

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