Yan Jia, Xu Jinnan, Wang Fan, Gao Yi, Qi Chuanyu, Chen Tiannan, Yan Jia
Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dev Neurosci. 2025;47(5):383-399. doi: 10.1159/000542005. Epub 2024 Oct 14.
In contemporary medical practice, general anesthesia plays an essential role in pediatric surgical procedures. While modern anesthetic protocols have demonstrated safety and efficacy across various pathological conditions, concerns persist regarding the potential neurotoxic effects associated with early exposure to general anesthesia.
Current research primarily examines the neurocognitive developmental impacts, with limited focus on neurobehavioral developmental disorders. This review presents a comprehensive analysis of clinical trial results related to five critical neurobehavioral developmental disorders: fine motor disability, attention-deficit hyperactivity disorder, impulse control disorders, autism spectrum disorder, and developmental coordination disorder. Furthermore, this review synthesizes insights from basic research on the potential toxicological mechanisms of general anesthetic agents that could influence clinical neurobehavioral changes. These findings provide valuable guidance for the prudent and safe utilization of anesthetic agents in pediatric patients.
This review explores the potential connections between general anesthesia and five neurobehavioral disorders, highlighting the importance of cautious anesthetic use in children in light of current research findings.
在当代医学实践中，全身麻醉在儿科外科手术中起着至关重要的作用。虽然现代麻醉方案已在各种病理状况下证明了安全性和有效性，但对于早期接触全身麻醉潜在的神经毒性影响仍存在担忧。
当前研究主要考察神经认知发育影响，对神经行为发育障碍的关注有限。本综述对与五种关键神经行为发育障碍相关的临床试验结果进行了全面分析：精细运动残疾、注意力缺陷多动障碍、冲动控制障碍、自闭症谱系障碍和发育性协调障碍。此外，本综述综合了基础研究中关于可能影响临床神经行为变化的全身麻醉药物潜在毒理学机制的见解。这些发现为儿科患者麻醉药物的谨慎和安全使用提供了有价值的指导。
本综述探讨了全身麻醉与五种神经行为障碍之间的潜在联系，根据当前研究结果强调了在儿童中谨慎使用麻醉的重要性。
