维生素 D 和镁水平与 COVID-19 患者严重程度和死亡率的关系。

Association of Vitamin D and magnesium levels with severity and mortality in patients with COVID-19.

机构信息

Servicio de Urgencias, Hospital General Salvador Zubirán Anchondo, Chihuahua, Chihuahua.

Department of Internal Medicine, Hospital Rebren, Durango, Durango.

出版信息

Cir Cir. 2024;92(5):603-607. doi: 10.24875/CIRU.23000514.

DOI:10.24875/CIRU.23000514

PMID:39401770

Abstract

OBJECTIVE

The study aimed to determine the association between serum magnesium and Vitamin D levels with the severity and mortality by coronavirus disease 19 (COVID-19) in hospitalized patients.

METHOD

Men and women over 18 years of age with probable COVID-19 were enrolled in a case-control study. Patients with a positive or negative test for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were allocated into case or control groups, respectively. Vitamin D deficiency was defined by concentrations < 20 ng/mL and hypomagnesemia by serum levels < 1.8 mg/dL.

RESULTS

A total of 54 patients, 30 women and 24 men, were enrolled and allocated into the groups with (n = 27) and without (n = 27) COVID-19. The logistic regression analysis showed that Vitamin D deficiency (odds ratio [OR] = 6.13; 95% confidence intervals [CI]: 1.32-28.34) and insufficiency (OR = 0.12; 95% CI: 0.02-0.60) are significantly associated with hospitalization. However, Vitamin D disorders and hypomagnesemia were not associated with mortality.

CONCLUSIONS

The results of the present study revealed that Vitamin D disturbances, but not hypomagnesemia, are associated with the severity of SARS-CoV-2.

摘要

目的

本研究旨在确定血清镁和维生素 D 水平与住院患者中 2019 年冠状病毒病（COVID-19）严重程度和死亡率的关系。

方法

纳入了年龄在 18 岁以上的疑似 COVID-19 的男性和女性患者。将 SARS-CoV-2 检测呈阳性或阴性的患者分别分配到病例组和对照组。维生素 D 缺乏定义为浓度<20ng/ml，低镁血症定义为血清水平<1.8mg/dL。

结果

共纳入 54 例患者，其中 30 例为女性，24 例为男性，分为 COVID-19 组（n=27）和非 COVID-19 组（n=27）。Logistic 回归分析显示，维生素 D 缺乏（比值比[OR]=6.13；95%置信区间[CI]：1.32-28.34）和不足（OR=0.12；95%CI：0.02-0.60）与住院显著相关。然而，维生素 D 紊乱和低镁血症与死亡率无关。