Clustering of chromosomal breakpoints in neoplasia.

It is becoming increasingly difficult to assimilate in a meaningful fashion the wealth of new information regarding chromosomal changes in human cancer. Compilation and analysis of this data is essential if a clear picture of the incidence and specificity of cancer associated chromosome abnormalities is to be seen. This report provides an overview of our most recent and comprehensive analyses on chromosomal changes in 5345 neoplasms, providing further evidence for a clustering of chromosomal breakpoints in human neoplasia.