National Key Laboratory of Quality Assurance and Sustainable Utilization of Authentic Medicinal Materials, Chinese Medicine Resource Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Foshan Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Foshan 528000, China.
J Ethnopharmacol. 2024 May 23;326:117850. doi: 10.1016/j.jep.2024.117850. Epub 2024 Feb 6.
Parkinson's disease (PD) is the most common progressive neurodegenerative disorder affecting more than 10 million people worldwide and is characterized by the progressive loss of Daergic (DA) neurons in the substantia nigra pars compacta. It has been reported that signaling pathways play a crucial role in the pathogenesis of PD, while the active ingredients of traditional Chinese medicine (TCM) have been found to possess a protective effect against PD. TCM has demonstrated significant potential in mitigating oxidative stress (OS), neuroinflammation, and apoptosis of DA neurons via the regulation of signaling pathways associated with PD.
This study discussed and analyzed the signaling pathways involved in the occurrence and development of PD and the mechanism of active ingredients of TCM regulating PD via signaling pathways, with the aim of providing a basis for the development and clinical application of therapeutic strategies for TCM in PD.
With "Parkinson's disease", "Idiopathic Parkinson's Disease", "Lewy Body Parkinson's Disease", "Parkinson's Disease, Idiopathic", "Parkinson Disease, Idiopathic", "Parkinson's disorders", "Parkinsonism syndrome", "Traditional Chinese medicine", "Chinese herbal medicine", "active ingredients", "medicinal plants" as the main keywords, PubMed, Web of Science and other online search engines were used for literature retrieval.
PD exhibits a close association with various signaling pathways, including but not limited to MAPKs, NF-κB, PI3K/Akt, Nrf2/ARE, Wnt/β-catenin, TLR/TRIF, NLRP3, Notch. The therapeutic potential of TCM lies in its ability to regulate these signaling pathways. In addition, the active ingredients of TCM have shown significant effects in improving OS, neuroinflammation, and DA neuron apoptosis in PD.
The active ingredients of TCM have unique advantages in regulating PD-related signaling pathways. It is suggested to combine network pharmacology and bioinformatics to study the specific targets of TCM. This not only provides a new way for the prevention and treatment of PD with the active ingredients of TCM, but also provides a scientific basis for the selection and development of TCM preparations.
帕金森病（PD）是一种最常见的进行性神经退行性疾病，影响着全球超过 1000 万人，其特征是黑质致密部的多巴胺能（DA）神经元进行性丧失。据报道，信号通路在 PD 的发病机制中起着至关重要的作用，而中药的活性成分已被发现对 PD 具有保护作用。中药在减轻氧化应激（OS）、神经炎症和 DA 神经元凋亡方面表现出显著的潜力，其作用机制是通过调节与 PD 相关的信号通路。
本研究讨论和分析了与 PD 的发生和发展相关的信号通路，以及中药活性成分通过信号通路调节 PD 的机制，旨在为 PD 中药治疗策略的开发和临床应用提供依据。
以“帕金森病”、“特发性帕金森病”、“路易体帕金森病”、“特发性帕金森病，帕金森病”、“帕金森病，特发性”、“帕金森病”、“帕金森病样综合征”、“传统中药”、“中草药”、“活性成分”、“药用植物”为主要关键词，通过 PubMed、Web of Science 等在线搜索引擎进行文献检索。
PD 与各种信号通路密切相关，包括但不限于 MAPKs、NF-κB、PI3K/Akt、Nrf2/ARE、Wnt/β-catenin、TLR/TRIF、NLRP3、Notch。中药的治疗潜力在于其调节这些信号通路的能力。此外，中药的活性成分在改善 PD 中的 OS、神经炎症和 DA 神经元凋亡方面显示出显著的效果。
中药的活性成分在调节 PD 相关信号通路方面具有独特的优势。建议结合网络药理学和生物信息学研究中药的具体靶点。这不仅为中药活性成分防治 PD 提供了新途径，也为中药制剂的选择和开发提供了科学依据。
