Department of Psychology, University of Jyvaskyla, Jyväskylä, Finland.
Human Information Processing Laboratory, Faculty of Social Sciences/Psychology, Tampere University, Tampere, Finland.
Eur J Neurosci. 2024 Nov;60(10):6440-6469. doi: 10.1111/ejn.16569. Epub 2024 Oct 14.
Depression is a heterogeneous syndrome that impacts an individual's emotional, social, cognitive and bodily functioning. Depression is associated with biases in emotional processing, but alterations in basic sensory processing have received less attention in depression research. Here, we measured event-related potentials (ERPs) in response to changes in the intensity of auditory stimuli and the location of somatosensory stimuli in participants with depression and in non-depressed control participants. We tested whether auditory mismatch negativity, P3a or N1 intensity dependence response or somatosensory mismatch response, P3a, P50 or N80 can dissociate depressed participants and non-depressed controls, and we also analysed the effects of depression medication and age in this sample. N1 intensity dependence response was increased in unmedicated depressed participants relative to non-depressed controls. When age was controlled for in the analysis, the effect of depression was only at a trend level. N1 intensity dependence response correlated with depression severity at the whole sample level. We did not observe any depression-related alterations in auditory mismatch negativity or P3a or somatosensory ERPs. Our results may reflect an association between the N1 intensity dependence response and altered neurotransmitter activity in depression, but this should be confirmed in future studies.
抑郁症是一种影响个体情绪、社交、认知和身体功能的异质综合征。抑郁症与情绪处理的偏差有关，但在抑郁症研究中，对基本感觉处理的改变关注较少。在这里，我们在抑郁症患者和非抑郁对照组参与者中测量了对听觉刺激强度变化和躯体感觉刺激位置的事件相关电位（ERP）。我们测试了听觉失匹配负波、P3a 或 N1 强度依赖性反应或躯体感觉失匹配反应、P3a、P50 或 N80 是否可以区分抑郁患者和非抑郁对照组，我们还分析了该样本中抑郁药物和年龄的影响。与非抑郁对照组相比，未接受药物治疗的抑郁患者的 N1 强度依赖性反应增加。在分析中控制年龄后，抑郁的影响仅处于趋势水平。N1 强度依赖性反应与全样本水平的抑郁严重程度相关。我们没有观察到听觉失匹配负波或 P3a 或躯体感觉 ERP 与抑郁相关的任何改变。我们的结果可能反映了 N1 强度依赖性反应与抑郁中改变的神经递质活性之间的关联，但这应在未来的研究中得到证实。
