Lanzhou University, Lanzhou, Gansu, People's Republic of China.
Department of Endocrinology Genetic Metabolism, Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, 730000, Gansu, People's Republic of China.
Sci Rep. 2024 Oct 14;14(1):24061. doi: 10.1038/s41598-024-74339-y.
Weight-adjusted waist index (WWI) is a new marker of central obesity. This study explored the association of WWI with all-cause and cardiovascular disease (CVD) mortality in individuals with diabetes or prediabetes. 6551 participants with diabetes or prediabetes from the National Health and Nutrition Examination Survey (NHANES) records between 2005 and 2018 were included. The association of WWI with all-cause and CVD mortality was assessed using Kaplan-Meier survival analysis, Cox proportional hazards model (Cox regression), and restricted cubic spline (RCS). The predictive value of WWI for mortality was analyzed using time-dependent receiver operating characteristic curves (ROC). There were 1083 all-cause deaths and 360 CVD deaths. Multivariable-adjusted Cox regression analyses showed WWI was positively correlated with the risk of all-cause and CVD mortality in subjects with diabetes or prediabetes. Multivariate-adjusted RCS analyses showed a linear and positive correlation of WWI with all-cause mortality risk, and a nonlinear relationship with CVD mortality, with a threshold of 12.35. The area under the curve (AUC) for 3, 5, and 10-years survival for all-cause mortality was 0.795, 0.792, and 0.812, respectively, and for CVD mortality was 0.815, 0.833, and 0.831, respectively. WWI is a valuable predictor of all-cause mortality risk in patients with diabetes and prediabetes, and a valuable predictor of CVD mortality risk when patients with diabetes and prediabetes are considered as a whole.
体重调整腰围指数（WWI）是一种新的中心性肥胖标志物。本研究探讨了 WWI 与糖尿病或糖尿病前期个体全因和心血管疾病（CVD）死亡率的相关性。纳入了 2005 年至 2018 年期间国家健康和营养检查调查（NHANES）记录中的 6551 例糖尿病或糖尿病前期患者。使用 Kaplan-Meier 生存分析、Cox 比例风险模型（Cox 回归）和限制性立方样条（RCS）评估 WWI 与全因和 CVD 死亡率的相关性。使用时间依赖性接受者操作特征曲线（ROC）分析 WWI 对死亡率的预测价值。共有 1083 例全因死亡和 360 例 CVD 死亡。多变量调整后的 Cox 回归分析表明，WWI 与糖尿病或糖尿病前期患者的全因和 CVD 死亡率风险呈正相关。多变量调整后的 RCS 分析表明，WWI 与全因死亡率风险呈线性正相关，与 CVD 死亡率呈非线性相关，阈值为 12.35。全因死亡率 3、5 和 10 年生存率的曲线下面积（AUC）分别为 0.795、0.792 和 0.812，CVD 死亡率的 AUC 分别为 0.815、0.833 和 0.831。WWI 是糖尿病和糖尿病前期患者全因死亡风险的有价值预测指标，也是糖尿病和糖尿病前期患者整体 CVD 死亡风险的有价值预测指标。
