Guo Shaoyi, Chen Dan, Zhang Yunfeng, Cao Kaiqi, Xia Yongqi, Yang Dejin
Department of Orthopaedic Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, China.
BMC Musculoskelet Disord. 2025 Apr 21;26(1):390. doi: 10.1186/s12891-025-08638-4.
The Weight-Adjusted waist index (WWI) is a novel obesity assessment parameter that has been shown to be associated with mortality in various chronic disease populations and is also linked to the onset of osteoarthritis (OA). The aim of this study is to investigate whether WWI is associated with all-cause and cardiovascular mortality in OA population.
The study analyzed a cohort of 3,554 OA patients drawn from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2018. Kaplan-Meier survival curves, Cox proportional hazards regression models, and subgroup analyses were utilized to assess the association between WWI and mortality outcomes. The dose-response relationship was examined using a restricted cubic spline (RCS) model.
Among the 3,554 OA individuals, 611 participants were determined as deceased (13%), and 26% of the deaths were due to cardiovascular causes. The fully adjusted Cox proportional hazards model revealed that elevated WWI values were significantly associated with a higher risk of all-cause mortality (HR = 1.28, 95% CI 1.07‒1.52). The association between WWI and cardiovascular mortality in OA patients was only observed in the minimally adjusted model (HR = 1.43, 95% CI 1.12‒1.81). A similar conclusion was observed when the participants were grouped according to WWI tertiles. Kaplan-Meier survival curves demonstrated elevated mortality rates among individuals with higher WWI. The dose-response analysis indicated a linear positive relationship between WWI and mortality rates. The above associations remained consistent across all subgroups.
Elevated WWI levels were associated with a higher risk of all-cause mortality in OA individuals independently.
Not applicable.
体重调整腰围指数（WWI）是一种新型肥胖评估参数，已被证明与各种慢性病患者的死亡率相关，还与骨关节炎（OA）的发病有关。本研究的目的是调查WWI是否与OA患者的全因死亡率和心血管死亡率相关。
该研究分析了从2005年至2018年进行的美国国家健康与营养检查调查（NHANES）中抽取的3554名OA患者队列。采用Kaplan-Meier生存曲线、Cox比例风险回归模型和亚组分析来评估WWI与死亡率结局之间的关联。使用受限立方样条（RCS）模型检查剂量反应关系。
在3554名OA个体中，611名参与者被确定为死亡（13%），26%的死亡是由心血管原因导致的。完全调整后的Cox比例风险模型显示，较高的WWI值与全因死亡率较高风险显著相关（HR = 1.28，95%CI 1.07‒1.52）。仅在最小调整模型中观察到OA患者中WWI与心血管死亡率之间的关联（HR = 1.43，95%CI 1.12‒1.81）。当根据WWI三分位数对参与者进行分组时，观察到了类似的结论。Kaplan-Meier生存曲线显示，WWI较高的个体死亡率较高。剂量反应分析表明WWI与死亡率之间存在线性正相关关系。上述关联在所有亚组中均保持一致。
OA个体中较高的WWI水平独立地与全因死亡率较高风险相关。
不适用。
