Hepburn P J, Masters J R
Cancer Chemother Pharmacol. 1986;16(1):80-2. doi: 10.1007/BF00255293.
To assess the influence of clonogenic assay methodology on measurement of reproductive cell kill, the in vitro sensitivities of a human bladder cancer cell line, RT112, to methotrexate and adriamycin were determined using ten different procedures. Marked differences in dose-response to methotrexate, but not adriamycin, were observed.