SEA-AD是一个针对阿尔茨海默病的多模态细胞图谱和资源。
SEA-AD is a multimodal cellular atlas and resource for Alzheimer's disease.
作者信息
Hawrylycz Michael, Kaplan Eitan S, Travaglini Kyle J, Gabitto Mariano I, Miller Jeremy A, Ng Lydia, Close Jennie L, Hodge Rebecca D, Long Brian, Mollenkopf Tyler, Mufti Shoaib, Gatto Nicole M, Larson Eric B, Crane Paul K, Grabowski Thomas J, Keene C Dirk, Lein Ed S
机构信息
Allen Institute for Brain Science, Seattle, WA, USA.
Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
出版信息
Nat Aging. 2024 Oct;4(10):1331-1334. doi: 10.1038/s43587-024-00719-8.
Abstract
The Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) is a multifaceted open data resource designed to identify cellular and molecular pathologies that underlie Alzheimer’s disease. Integrating neuropathology, single cell and spatial genomics, and longitudinal clinical metadata, SEA-AD is a unique resource for studying the pathogenesis of Alzheimer’s and related dementias.
摘要
西雅图阿尔茨海默病脑细胞图谱（SEA-AD）是一个多方面的开放数据资源，旨在识别阿尔茨海默病潜在的细胞和分子病理学特征。SEA-AD整合了神经病理学、单细胞和空间基因组学以及纵向临床元数据，是研究阿尔茨海默病及相关痴呆症发病机制的独特资源。
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