Poralla T, Manns M, Hütteroth T H, Hess G, Dormeyer H H, Meyer zum Büschenfelde K H
Digestion. 1986;33(1):53-60. doi: 10.1159/000199274.
During a period of 3 years we observed 5 patients with chronic active hepatitis B and 2 with hepatitis B virus-induced liver cirrhosis who cleared HBsAg from their sera after 2-14 years of HBsAg carriership. 4 of them developed anti-HBs. After HBsAg clearance there was no evidence of persisting inflammatory activity within their livers. 5 of the 7 patients had been treated for 1-39 months with prednisolone, sometimes in combination with azathioprine. This therapy, however, had been stopped more than 3 years before these patients terminated their HBsAg carriership. Our observations indicate that even after long-standing chronic active hepatitis B or hepatitis B virus-induced liver cirrhosis HBsAg may be eliminated in a considerable number of patients.
在3年的时间里，我们观察到5例慢性活动性乙型肝炎患者和2例乙型肝炎病毒所致肝硬化患者，他们在血清乙肝表面抗原（HBsAg）携带2 - 14年后血清中的HBsAg转阴。其中4例产生了抗-HBs。HBsAg转阴后，肝脏内无持续炎症活动的证据。7例患者中有5例曾接受泼尼松龙治疗1 - 39个月，有时联合硫唑嘌呤。然而，在这些患者结束HBsAg携带状态3年多以前就已停止该治疗。我们的观察表明，即使是长期的慢性活动性乙型肝炎或乙型肝炎病毒所致肝硬化患者，仍有相当一部分可能清除HBsAg。
