Toscano V, Horton R
J Clin Invest. 1987 Jun;79(6):1653-8. doi: 10.1172/JCI113003.
We compared the blood (PBDHT) and urine (PUDHT) production rate of dihydrotestosterone (DHT) in normal men and women to determine whether peripheral formation was totally reflected in blood. PBDHT was similar when measured at both sites in men (674 +/- 79 vs. 788 +/- 207 SE micrograms/d); however, PUDHT was greater than PBDHT in women (174 +/- 55 vs. 55 +/- 8 micrograms/d, P less than 0.02). Excretion rates of DHT and 3 alpha-androstanediol (3 alpha diol) were similar in both sexes despite major differences in blood levels. However, between sexes large differences were present in 3 alpha diol glucuronide (3 alpha diolG) in both plasma and urine. These observations indicate that peripheral (renal) formation of DHT and probably 3 alpha diol were not accurately determined by measurement of these steroids in blood. The large difference between blood and urine production rates in women suggests an important role of non-testosterone precursors of 5 alpha-reduced steroids. Measurements of 3 alpha diolG may provide more insight into these peripheral events.
我们比较了正常男性和女性中双氢睾酮（DHT）的血液生成率（PBDHT）和尿液生成率（PUDHT），以确定外周生成是否完全反映在血液中。在男性中，两个部位测得的PBDHT相似（674±79对788±207 SE微克/天）；然而，女性的PUDHT大于PBDHT（174±55对55±8微克/天，P<0.02）。尽管血液水平存在重大差异，但DHT和3α-雄烷二醇（3α二醇）的排泄率在两性中相似。然而，两性之间血浆和尿液中的3α二醇葡萄糖醛酸苷（3α二醇G）存在很大差异。这些观察结果表明，通过测量血液中的这些类固醇并不能准确确定DHT以及可能的3α二醇的外周（肾脏）生成。女性血液和尿液生成率之间的巨大差异表明5α-还原类固醇的非睾酮前体具有重要作用。测量3α二醇G可能会为这些外周事件提供更多见解。
