Bi Yucong, Zheng Liping, Zhang Leping, Han Longyang, Liu Yang, Zheng Xiaowei, Zhong Chongke
Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, 199 Renai Road, Industrial Park District, Suzhou, Jiangsu Province, 215123, China.
The First Hospital of Jiaxing, Jiaxing, China.
Arch Public Health. 2024 Oct 14;82(1):181. doi: 10.1186/s13690-024-01390-6.
Previous studies have reported that anemia was associated with depression, but the association between changes in depressive symptoms and the risk of anemia was unclear. This study aimed to explore whether changes in depressive symptoms were associated with anemia among the middle-aged and elderly adults.
A total of 6112 patients aged 45 years and older from the China Health and Retirement Longitudinal Study (CHARLS) were included in this analysis. Elevated Depression Symptoms (EDS) was defined as the Center for Epidemiological Studies Depression Scale-10 score ≥ 10. Depression status was defined as no depressive symptom [no EDS at Wave 1 (2011-2012) and Wave 2 (2013-2014)], decreasing depressive symptoms (EDS at Wave 1, no EDS at Wave 2), increasing depressive symptoms (no EDS at Wave 1, EDS at Wave 2), persistent depressive symptoms (EDS at Wave 1 and Wave 2). Multivariable logistic regression analyses were conducted to estimate the relationships between depressive symptoms and the changes and risk of anemia.
During the follow-up of Wave 1 and Wave 3 (2015-2016), 906 participants (14.82%) developed anemia, the multivariable-adjusted odds ratio for the depressive symptom compared with the no depressive symptom was 1.24 (95% CI, 1.12-1.58) for anemia. From Wave 2 to Wave 3, there were 828 participants (14.62%) diagnosed with anemia. Compared to participants with no depressive symptom, those with persistent depressive symptoms during Wave 1 and Wave 2 had the significantly elevated risk of anemia (odds ratio 1.44, 95% CI 1.21-1.84).
The present study demonstrated that baseline depressive symptoms and changes in depressive symptoms were associated with increased risks of anemia.
既往研究报道贫血与抑郁症有关，但抑郁症状变化与贫血风险之间的关联尚不清楚。本研究旨在探讨中年及老年人群中抑郁症状变化是否与贫血有关。
本分析纳入了中国健康与养老追踪调查（CHARLS）中6112名年龄在45岁及以上的患者。抑郁症状加重（EDS）定义为流行病学研究中心抑郁量表-10得分≥10分。抑郁状态定义为无抑郁症状[在第1波（2011 - 2012年）和第2波（2013 - 2014年）时无EDS]、抑郁症状减轻（第1波时有EDS，第2波时无EDS）、抑郁症状加重（第1波时无EDS，第2波时有EDS）、持续性抑郁症状（第1波和第2波时均有EDS）。进行多变量逻辑回归分析以估计抑郁症状与贫血变化及风险之间的关系。
在第1波和第3波（2015 - 2016年）的随访期间，906名参与者（14.82%）发生贫血，与无抑郁症状相比，抑郁症状的多变量调整后贫血比值比为1.24（95%CI，1.12 - 1.58）。从第2波到第3波，有828名参与者（14.62%）被诊断为贫血。与无抑郁症状的参与者相比，在第1波和第2波期间有持续性抑郁症状的参与者贫血风险显著升高（比值比1.44，95%CI 1.21 - 1.84）。
本研究表明基线抑郁症状和抑郁症状变化与贫血风险增加有关。
