Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, China.
Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, China.
J Affect Disord. 2020 Apr 1;266:187-193. doi: 10.1016/j.jad.2020.01.054. Epub 2020 Jan 15.
Association of cardiovascular disease (CVD) or depression and memory has been studied. But hardly any studies on the association of coexistence of CVD and depression and memory.
This is a prospective cohort study of a nationally representative sample of 12,272 adults aged 45 years and more who participated in the China health and retirement longitudinal study 2011 to 2015. All variables were acquired by self-reporting questions. The associations between coexistence of CVD and depression with memory related disease (MRD) were investigated by using Cox proportional hazards regression models.
Among the 12,272 participants (mean age 65.69 years; 46.8% male) in this study, 56.9% no CVD or depression and 6.7% coexistence of CVD and depression. After adjustment for age, sex, marriage, living place, registered permanent residence, education level, smoking status, alcoholic intake, sleep status, nap status, social communication, health before 15 years, life satisfaction, cognitive function, and 11 chronic diseases risk factors, depression alone was significantly high risk for MRD (HR:1.64; 95% CI: 1.09-2.49); coexistence of CVD and depression increased the risk for MRD significantly higher (HR: 4.72; 95%CI: 2.91-7.64).
Diseases were all self-reported and we couldn't adjust for all the potential confounders, which might be prone to information error and residual confounding.
In a nationally representative cohort with median 4 years of follow-up, depression alone and co-existence of depression and CVD could significantly increase the risk of MRD. Our study supports the idea of prevention of memory disease from a psycho-cardiology aspect.
心血管疾病 (CVD) 或抑郁与记忆之间的关联已有研究。但几乎没有研究关注 CVD 和抑郁共存与记忆障碍之间的关联。
这是一项针对全国代表性样本的前瞻性队列研究，共有 12272 名年龄在 45 岁及以上的成年人参加了 2011 年至 2015 年的中国健康与退休纵向研究。所有变量均通过自我报告的问题获得。使用 Cox 比例风险回归模型研究 CVD 和抑郁共存与记忆相关疾病 (MRD) 之间的关联。
在这项研究的 12272 名参与者中（平均年龄 65.69 岁；46.8%为男性），56.9%无 CVD 或抑郁，6.7%同时存在 CVD 和抑郁。在调整年龄、性别、婚姻状况、居住地点、户籍、教育程度、吸烟状况、饮酒量、睡眠状况、午睡状况、社会交往、15 年前健康状况、生活满意度、认知功能和 11 种慢性病危险因素后，抑郁本身是 MRD 的高风险因素（HR：1.64；95%CI：1.09-2.49）；CVD 和抑郁共存显著增加了 MRD 的风险（HR：4.72；95%CI：2.91-7.64）。
疾病均为自我报告，我们无法调整所有潜在的混杂因素，这可能容易导致信息错误和残留混杂。
在一项具有中位数 4 年随访时间的全国代表性队列中，单独的抑郁以及抑郁和 CVD 的共存都会显著增加 MRD 的风险。我们的研究支持从心理心脏病学角度预防记忆疾病的观点。
