病理性人格维度与神经生物学情绪反应性
Pathological personality dimensions and neurobiological emotional reactivity.
作者信息
Barkley Sarah B, Feldman Jacob, Levy Adina, Grieshaber Alex, Nelson Brady D
机构信息
Department of Psychology, Stony Brook University, Psychology B Building, Stony Brook, NY, USA.
Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.
出版信息
Psychol Med. 2024 Oct 15;54(13):1-8. doi: 10.1017/S0033291724001946.
BACKGROUND
The Hierarchical Taxonomy of Psychopathology (HiTOP) offers a promising framework to identify the neurobiological mechanisms of psychopathology. Many forms of psychopathology are characterized by dysfunctional emotional reactivity. The late positive potential (LPP) is an event-related potential component that provides an index of neurobiological emotional reactivity. Several categorical disorders have demonstrated a similar association with the emotion-modulated LPP. It is possible that higher-order dimensional representations of psychopathology might explain the comparable results. The present study examined the association between HiTOP-consistent pathological personality dimensions across multiple levels of the hierarchy and neurobiological emotional reactivity.
METHODS
The sample included 215 18-35-year-old adults (86% female) who were oversampled for psychopathology. Participants completed the emotional interrupt task while electroencephalography was recorded to examine the LPP. Participants also completed the Comprehensive Assessment of Traits relevant to Personality Disorders to assess pathological personality.
RESULTS
At the spectra level, higher negative emotionality was associated with a larger emotion-modulated LPP, while higher detachment was associated with a smaller emotion-modulated LPP. There were no associations between higher-order psychopathology levels and the emotion-modulated LPP. Compared to categorical diagnoses, spectra-level personality pathology dimensions significantly improved the prediction of the emotion-modulated LPP.
CONCLUSIONS
The present study indicates that HiTOP spectra levels of negative emotionality and detachment demonstrate unique associations with neurobiological emotional reactivity. The study highlights the utility of examining dimensional and hierarchical, rather than categorical, representations of psychopathology in the attempt to identify the neurobiological origins of psychopathology.
背景
精神病理学层次分类法（HiTOP）为识别精神病理学的神经生物学机制提供了一个有前景的框架。许多精神病理学形式的特征是情绪反应功能失调。晚期正电位（LPP）是一种事件相关电位成分，可提供神经生物学情绪反应的指标。几种分类障碍已显示出与情绪调节的LPP有类似关联。精神病理学的高阶维度表征可能解释这些可比结果。本研究考察了HiTOP一致的跨层次病理人格维度与神经生物学情绪反应之间的关联。
方法
样本包括215名18至35岁的成年人（86%为女性），这些人因精神病理学问题被过度抽样。参与者在进行脑电图记录以检查LPP时完成情绪中断任务。参与者还完成了与人格障碍相关特质的综合评估以评估病理人格。
结果
在频谱水平上，较高的负性情绪与较大的情绪调节LPP相关，而较高的超脱与较小的情绪调节LPP相关。高阶精神病理学水平与情绪调节的LPP之间无关联。与分类诊断相比，频谱水平的人格病理维度显著改善了对情绪调节LPP的预测。
结论
本研究表明，HiTOP频谱水平的负性情绪和超脱与神经生物学情绪反应存在独特关联。该研究强调了在试图识别精神病理学的神经生物学起源时，检查精神病理学的维度和层次而非分类表征的效用。
Zotero 插件