Bickel Etienne, Kazmaier Uli
Institute of Organic Chemistry, Saarland University, P.O. Box 151150, 66041 Saarbrücken, Germany.
Org Biomol Chem. 2024 Nov 13;22(44):8811-8816. doi: 10.1039/d4ob01373e.
New bottromycin derivatives have been prepared using flexible Ugi and Matteson reactions. The Ugi reaction allows the fast and direct assembly of sterically hindered peptide fragments, while the Matteson homologation is excellently suited for the stereoselective synthesis of unusual amino acids like β-methylphenylalanine. Some of the new compounds show excellent activity against .
新型底部霉素衍生物已通过灵活的乌吉反应和马特森反应制备而成。乌吉反应能够快速直接地组装位阻肽片段，而马特森同系化反应则非常适合立体选择性合成诸如β-甲基苯丙氨酸等特殊氨基酸。一些新化合物对……显示出优异的活性。
