• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

JAK抑制剂的新前沿：托法替布对臀部填充剂肉芽肿反应患者有显著治疗效果

The New Frontier of JAK Inhibitors: Significant Therapeutic Response to Tofacitinib in a Patient With Granulomatous Reaction to Filler in the Buttocks.

作者信息

Mansouri Parvin, Farshi Susan

机构信息

Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Cosmet Dermatol. 2024 Dec;23(12):3924-3926. doi: 10.1111/jocd.16578. Epub 2024 Oct 15.

DOI:10.1111/jocd.16578
PMID:39403005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11626294/
Abstract

BACKGROUND

Recent research has demonstrated that Janus Kinase (JAK) inhibitors can be effective in treating refractory granulomatous diseases.

CASE PRESENTATION

We report the case of a 50-year-old woman who developed a granulomatous reaction following a filler injection in her buttocks.

MANAGEMENT

The patient was treated with tofacitinib, and after 1 year of therapy, the stiffness and swelling resolved without any side effects.

CONCLUSION

Tofacitinib appears to be a viable option for the treatment of granulomatous reactions to fillers.

摘要

背景

近期研究表明，Janus激酶（JAK）抑制剂可有效治疗难治性肉芽肿性疾病。

病例介绍

我们报告一例50岁女性病例，该患者在臀部注射填充剂后发生肉芽肿反应。

治疗

患者接受托法替布治疗，治疗1年后，僵硬和肿胀消退，且无任何副作用。

结论

托法替布似乎是治疗填充剂所致肉芽肿反应的一种可行选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9936/11626294/090fa4a988ac/JOCD-23--g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9936/11626294/090fa4a988ac/JOCD-23--g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9936/11626294/090fa4a988ac/JOCD-23--g001.jpg

相似文献

1
The New Frontier of JAK Inhibitors: Significant Therapeutic Response to Tofacitinib in a Patient With Granulomatous Reaction to Filler in the Buttocks.JAK抑制剂的新前沿：托法替布对臀部填充剂肉芽肿反应患者有显著治疗效果
J Cosmet Dermatol. 2024 Dec;23(12):3924-3926. doi: 10.1111/jocd.16578. Epub 2024 Oct 15.
2
Tofacitinib for managing granuloma formation after dermal filler injection: three case reports and literature review.托法替尼治疗真皮填充剂注射后肉芽肿形成：三例报告及文献复习。
J Dermatolog Treat. 2024 Dec;35(1):2338281. doi: 10.1080/09546634.2024.2338281. Epub 2024 Apr 18.
3
Tofacitinib for the treatment of lichen planopilaris: A case series.托法替尼治疗扁平苔藓样毛囊炎：病例系列。
Dermatol Ther. 2018 Nov;31(6):e12656. doi: 10.1111/dth.12656. Epub 2018 Sep 27.
4
Efficacy and safety of tofacitinib for moderate-to-severe plaque psoriasis: a systematic review and meta-analysis of randomized controlled trials.托法替尼治疗中重度斑块状银屑病的疗效和安全性：系统评价和随机对照试验的荟萃分析。
J Eur Acad Dermatol Venereol. 2018 Mar;32(3):355-362. doi: 10.1111/jdv.14695. Epub 2017 Dec 5.
5
Real-World Experience with Tofacitinib in IBD at a Tertiary Center.真实世界中在三级中心使用托法替布治疗炎症性肠病的经验。
Dig Dis Sci. 2019 Jul;64(7):1945-1951. doi: 10.1007/s10620-019-05492-y. Epub 2019 Feb 7.
6
Case report: successful treatment of refractory SAPHO syndrome with the JAK inhibitor tofacitinib.病例报告：使用JAK抑制剂托法替布成功治疗难治性SAPHO综合征。
Medicine (Baltimore). 2018 Jun;97(25):e11149. doi: 10.1097/MD.0000000000011149.
7
Comparative Efficacy and Safety of Three Janus Kinase Inhibitors in Ulcerative Colitis: A Real-World Multicentre Study in Japan.三种 Janus 激酶抑制剂治疗溃疡性结肠炎的疗效和安全性比较：日本一项真实世界多中心研究
Aliment Pharmacol Ther. 2025 Feb;61(3):524-537. doi: 10.1111/apt.18406. Epub 2024 Nov 22.
8
Adverse drug events associated with 5mg versus 10mg Tofacitinib (Janus kinase inhibitor) twice daily for the treatment of autoimmune diseases: A systematic review and meta-analysis of randomized controlled trials.与每日两次 5mg 和 10mg 托法替尼（Janus 激酶抑制剂）治疗自身免疫性疾病相关的药物不良反应：系统评价和随机对照试验的荟萃分析。
Clin Rheumatol. 2019 Feb;38(2):523-534. doi: 10.1007/s10067-018-4299-4. Epub 2018 Sep 22.
9
Comparison of the Treatment Outcome of Oral Tofacitinib with Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study.口服托法替尼与其他常规疗法治疗难治性全秃和普秃的疗效比较：一项回顾性研究。
Acta Derm Venereol. 2019 Jan 1;99(1):41-46. doi: 10.2340/00015555-3057.
10
Exposure-response characterization of tofacitinib efficacy in moderate to severe ulcerative colitis: Results from a dose-ranging phase 2 trial.在中重度溃疡性结肠炎中评估托法替布疗效的暴露-反应特征：一项剂量范围的 2 期试验结果。
Br J Clin Pharmacol. 2018 Jun;84(6):1136-1145. doi: 10.1111/bcp.13523. Epub 2018 Mar 23.

引用本文的文献

1
Successful Treatment of Cutaneous Foreign Body Granuloma with JAK Inhibitor Abrocitinib and Prednisone: A Case Report.使用JAK抑制剂阿布昔替尼和泼尼松成功治疗皮肤异物肉芽肿：一例报告
Clin Cosmet Investig Dermatol. 2025 May 17;18:1199-1206. doi: 10.2147/CCID.S522469. eCollection 2025.

本文引用的文献

1
Novel Management of Granuloma Formation Secondary to Dermal Filler with Intralesional 1444 nm Nd:YAG Laser Technique.真皮内注射 1444nmNd:YAG 激光治疗填充剂后肉芽肿形成的新方法。
Medicina (Kaunas). 2023 Jul 31;59(8):1406. doi: 10.3390/medicina59081406.
2
Janus kinase inhibitors for treatment of morphea and systemic sclerosis: A literature review.Janus 激酶抑制剂治疗硬斑病和系统性硬化症：文献复习。
Dermatol Ther. 2022 Jun;35(6):e15437. doi: 10.1111/dth.15437. Epub 2022 Mar 22.
3
Full histological and clinical regression of morphea with tofacitinib.
托法替布治疗硬斑病实现完全组织学和临床缓解。
Clin Rheumatol. 2020 Sep;39(9):2827-2828. doi: 10.1007/s10067-020-05118-z. Epub 2020 May 18.
4
The Promise of JAK Inhibitors for Treatment of Sarcoidosis and Other Inflammatory Disorders with Macrophage Activation: A Review of the Literature.JAK 抑制剂治疗伴有巨噬细胞活化的结节病和其他炎症性疾病的前景：文献综述。
Yale J Biol Med. 2020 Mar 27;93(1):187-195. eCollection 2020 Mar.
5
Treatment of necrobiosis lipoidica with combination Janus kinase inhibition and intralesional corticosteroid.联合使用 Janus 激酶抑制剂和皮损内注射皮质类固醇治疗类脂质渐进性坏死。
JAAD Case Rep. 2020 Jan 24;6(2):133-135. doi: 10.1016/j.jdcr.2019.11.016. eCollection 2020 Feb.
6
Janus kinase inhibition induces disease remission in cutaneous sarcoidosis and granuloma annulare.Janus 激酶抑制可诱导皮肤结节病和环状肉芽肿缓解。
J Am Acad Dermatol. 2020 Mar;82(3):612-621. doi: 10.1016/j.jaad.2019.05.098. Epub 2019 Jun 8.
7
Treatment of generalized deep morphea and eosinophilic fasciitis with the Janus kinase inhibitor tofacitinib.用Janus激酶抑制剂托法替布治疗泛发性深部硬斑病和嗜酸性筋膜炎。
JAAD Case Rep. 2018 Apr 30;4(5):443-445. doi: 10.1016/j.jdcr.2017.12.003. eCollection 2018 Jun.