Wang Xu, Li Hongyan, Wang Gaihua, He Ziqiao, Cui Xueting, Song Feiyu, Li Jinhua, Zhang Lin
China-Japan Union Hospital, Jilin University, Changchun, Jilin, China.
School of Public Health, Jilin University, Jilin, China.
Front Nutr. 2024 Sep 25;11:1441062. doi: 10.3389/fnut.2024.1441062. eCollection 2024.
Ischemic stroke poses a significant global health challenge with limited treatment options. Tissue plasminogen activator, the only effective medication, has strict restrictions, limiting its benefits only to a small number of patients. Astaxanthin, a natural carotenoid found in algae, shrimp, and crabs, has demonstrated promising neuroprotective properties in models of ischemic stroke. This article reviews the novel finding of neuroprotective impact of astaxanthin in ischemic stroke, highlighting its benefits in various protective mechanisms such as antioxidation, anti-inflammation, enhancement of DNA repair, anti-cell death, protection of blood-brain barrier, and promotion of neuronal survival. This analysis underscores the therapeutic and preventive potential of astaxanthin in ischemic stroke, positioning it as a prospective pharmaceutical agent against ischemic stroke.
缺血性中风对全球健康构成重大挑战，且治疗选择有限。组织型纤溶酶原激活剂是唯一有效的药物，但有严格限制，仅能使少数患者受益。虾青素是一种存在于藻类、虾和蟹中的天然类胡萝卜素，在缺血性中风模型中已显示出有前景的神经保护特性。本文综述了虾青素对缺血性中风神经保护作用的新发现，强调了其在抗氧化、抗炎、增强DNA修复、抗细胞死亡、保护血脑屏障和促进神经元存活等多种保护机制中的益处。该分析强调了虾青素在缺血性中风中的治疗和预防潜力，使其成为一种针对缺血性中风的潜在药物。
