Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
Front Endocrinol (Lausanne). 2024 Sep 30;15:1433624. doi: 10.3389/fendo.2024.1433624. eCollection 2024.
Female infertility is a global issue that impacts on public health seriously and many mental disorders are observed in infertility groups.
To investigate the casual relationship between those, genome-wide association studies summary data of anxiety disorder (n=9,897), broad depression (n=322,580), major depressive disorder (n=480,359 and n=500,199), bipolar disorder (n=51,710), insomnia (n= 462,341), and female infertility (n=126,342) were extracted from the existing datasets and was analyzed through the two-sample mendelian randomization study. The following heterogeneity and sensitivity test were applied to ensure the robustness of results.
Based on inverse variance weighted results, major depressive disorder was associated with female infertility (P = 0.0001, odds ratio 1.396, 95 % confidence interval 1.175-1.658). No causal relationship was identified between the other four mental disorders and infertility. was found. Additionally, reverse mendelian randomization did not indicate a causal relationship among these disorders.
The early identification and management of anxiety symptoms in women of reproductive age, in conjunction with the effective treatment of major depressive disorder, may be crucial for preserving female fertility.
女性不孕是一个全球性问题，严重影响公共健康，许多精神障碍在不孕群体中观察到。
为了研究这些疾病之间的因果关系，我们从现有的数据集提取了焦虑症（n=9897）、广泛抑郁症（n=322580）、重度抑郁症（n=480359 和 n=500199）、双相情感障碍（n=51710）、失眠症（n=462341）和女性不孕（n=126342）的全基因组关联研究汇总数据，并通过两样本 Mendelian 随机化研究进行分析。应用了异质性和敏感性测试以确保结果的稳健性。
基于逆方差加权结果，重度抑郁症与女性不孕相关（P=0.0001，优势比 1.396，95%置信区间 1.175-1.658）。未发现其他四种精神障碍与不孕之间存在因果关系。此外，反向 Mendelian 随机化也未表明这些障碍之间存在因果关系。
在生育年龄的女性中早期识别和管理焦虑症状，以及有效治疗重度抑郁症，可能对保护女性生育能力至关重要。
