Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157 of Xiwu Road, Xi'an, People's Republic of China.
Sleep Breath. 2023 Oct;27(5):1875-1882. doi: 10.1007/s11325-023-02802-7. Epub 2023 Mar 6.
Sleep disorders are a risk factor for a wide variety of dysfunctions of endocrine, metabolic, cardiovascular, and neurological diseases. However, the risk of sleep disorders to female infertility has not been thoroughly explored. Our study aimed to examine whether or not sleep disorders increase the risk of female infertility.
Cross-sectional data on sleep disorders and fertility history were obtained from the National Health and Nutrition Examination Survey 2013-2018. Women aged 20 to 40 years old were enrolled in our study. Weighted multivariable logistic regression models and stratified analysis by age, smokers, and patient health questionnaire-9 (PHQ-9) score were conducted to estimate the effect of sleep disorders on female infertility.
Among 1820 reproductive-age females, 248 individuals had infertility and 430 individuals had sleep disorders. Two weighted logistic regression models found that sleep disorders were an independent risk factor for infertility. After adjusting for the covariates (age, race/ethnicity, marital status, education level, poverty income ratio, body mass index (BMI), waist circumference, PHQ-9 score, smokers, drinkers, and sleeping hours), the risk of infertility was 2.14-fold higher in individuals with sleep disorders than in those without. The further stratified analysis demonstrated that the relationship between sleep disorders and infertility was maintained and that the risk was higher particularly in infertile women aged 40-44 years, with PHQ-9 score greater than 10, and smokers.
A strong association was found between sleep disorders and female infertility, and the association remained after adjusting for other confounding factors.
睡眠障碍是内分泌、代谢、心血管和神经系统疾病多种功能障碍的一个危险因素。然而，睡眠障碍对女性不孕的风险尚未得到彻底探讨。我们的研究旨在检验睡眠障碍是否会增加女性不孕的风险。
我们从 2013-2018 年的国家健康和营养调查中获取了睡眠障碍和生育史的横断面数据。我们的研究纳入了年龄在 20 至 40 岁之间的女性。我们采用加权多变量逻辑回归模型和按年龄、吸烟者和患者健康问卷-9（PHQ-9）评分分层分析，以估计睡眠障碍对女性不孕的影响。
在 1820 名育龄女性中，有 248 人患有不孕，430 人患有睡眠障碍。两个加权逻辑回归模型发现，睡眠障碍是不孕的一个独立危险因素。在调整了协变量（年龄、种族/民族、婚姻状况、教育程度、贫困收入比、体重指数（BMI）、腰围、PHQ-9 评分、吸烟者、饮酒者和睡眠时间）后，患有睡眠障碍的个体不孕的风险比没有睡眠障碍的个体高 2.14 倍。进一步的分层分析表明，睡眠障碍与不孕之间的关系仍然存在，而且这种风险在年龄在 40-44 岁的不孕女性、PHQ-9 评分大于 10 分的女性和吸烟者中更高。
睡眠障碍与女性不孕之间存在很强的关联，且在调整其他混杂因素后这种关联仍然存在。
