Ayuthu Shriya, Chauhan Yashkumar D, Mirza Amna A, Saad Moyal Z, Bittla Parikshit, Paidimarri Sai Pavitra, Nath Tuheen Sankar
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2024 Sep 13;16(9):e69318. doi: 10.7759/cureus.69318. eCollection 2024 Sep.
Biologically active derivatives of vitamin A, known as retinoids, can be used to treat cutaneous T-cell lymphomas. Retinoids and their analogs can modulate cell proliferation, differentiation, and apoptosis, and alter the immune response. This study systematically evaluated the safety, efficacy, and tolerability of retinoids for the treatment of cutaneous T-cell lymphomas and considered its limitations, dosing-side effects, and technique with the intent to provide valuable insights for clinicians and patients regarding the treatment of cutaneous T-cell lymphomas with the retinoids. The literature search is conducted using Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) criteria yielding 16 relevant articles. This study explored the different facets of the role of retinoids in the treatment of cutaneous T-cell lymphomas. In conclusion, the available studies and research have shown that retinoids play an important role in the mild and early stages of cutaneous T-cell lymphoma. However, further investigation is required to explain the mechanism of action of retinoids and the impact of their side effects in patients with cutaneous T-cell lymphoma.
维生素A的生物活性衍生物，即类视黄醇，可用于治疗皮肤T细胞淋巴瘤。类视黄醇及其类似物可调节细胞增殖、分化和凋亡，并改变免疫反应。本研究系统评估了类视黄醇治疗皮肤T细胞淋巴瘤的安全性、有效性和耐受性，并考虑了其局限性、给药副作用和技术，旨在为临床医生和患者提供有关使用类视黄醇治疗皮肤T细胞淋巴瘤的有价值见解。文献检索采用系统评价和Meta分析的首选报告项目（PRISMA）标准，共获得16篇相关文章。本研究探讨了类视黄醇在皮肤T细胞淋巴瘤治疗中作用的不同方面。总之，现有研究表明类视黄醇在皮肤T细胞淋巴瘤的轻度和早期阶段发挥重要作用。然而，需要进一步研究来解释类视黄醇的作用机制及其副作用对皮肤T细胞淋巴瘤患者的影响。
