Huen Auris O, Kim Ellen J
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Suite 330S, Philadelphia, PA 19104, USA.
Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Boulevard, Suite 330S, Philadelphia, PA 19104, USA.
Dermatol Clin. 2015 Oct;33(4):715-29. doi: 10.1016/j.det.2015.05.007. Epub 2015 Aug 4.
Retinoids are natural and synthetic vitamin A analogs with effects on cell proliferation, differentiation, and apoptosis. They have significant activity in hematologic malignancies and have been studied extensively in cutaneous T-cell lymphoma. Retinoids bind to nuclear receptors and exert their effects through moderation of gene expression. Retinoic acid receptor and retinoic X receptor exert regulatory activity in vivo, binding to distinct ligands. Studies investigating systemic retinoids as monotherapy and in combination with other agents active against cutaneous lymphoma are reviewed. Side effects associated with retinoids include teratogenicity, dyslipidemias, and hypothyroidism, which should be carefully monitored in patients receiving treatment.
类视黄醇是天然和合成的维生素A类似物，对细胞增殖、分化和凋亡有影响。它们在血液系统恶性肿瘤中具有显著活性，并且在皮肤T细胞淋巴瘤中已得到广泛研究。类视黄醇与核受体结合，并通过调节基因表达发挥作用。维甲酸受体和维甲酸X受体在体内发挥调节活性，与不同的配体结合。本文综述了将全身性类视黄醇作为单一疗法以及与其他对皮肤淋巴瘤有效的药物联合使用的研究。与类视黄醇相关的副作用包括致畸性、血脂异常和甲状腺功能减退，在接受治疗的患者中应仔细监测这些副作用。
