Department of Microbiology, Konkuk University School of Medicine, Chungju 27478, Republic of Korea.
KU Open Innovation Center, Research Institute of Medical Science, Konkuk University School of Medicine, Chungju 27478, Republic of Korea.
J Microbiol Biotechnol. 2024 Nov 28;34(11):2143-2152. doi: 10.4014/jmb.2407.07039. Epub 2024 Aug 30.
Gamma herpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are key contributors to the development of various cancers through their ability to manipulate host cellular pathways. This review explores the intricate ways these viruses rewire host metabolic pathways to sustain viral persistence and promote tumorigenesis. We look into how EBV and KSHV induce glycolytic reprogramming, alter mitochondrial function, and remodel nucleotide and amino acid metabolism, highlighting the crucial role of lipid metabolism in these oncogenic processes. By understanding these metabolic alterations, which confer proliferative and survival advantages to the virus-infected cells, we can identify potential therapeutic targets and develop innovative treatment strategies for gamma herpesvirus-associated malignancies. Ultimately, this review underscores the critical role of metabolic reprogramming in gamma herpesvirus oncogenesis and its implications for precision medicine in combating virus-driven cancers.
γ 疱疹病毒，包括 Epstein-Barr 病毒 (EBV) 和卡波济肉瘤相关疱疹病毒 (KSHV)，通过操纵宿主细胞途径，是导致各种癌症发展的主要因素。本综述探讨了这些病毒改变宿主代谢途径以维持病毒持续性和促进肿瘤发生的复杂方式。我们研究了 EBV 和 KSHV 如何诱导糖酵解重编程、改变线粒体功能以及重塑核苷酸和氨基酸代谢，强调了脂代谢在这些致癌过程中的关键作用。通过了解这些代谢改变，这些改变赋予病毒感染细胞增殖和存活优势，我们可以确定潜在的治疗靶点，并为 γ 疱疹病毒相关恶性肿瘤开发创新的治疗策略。最终，本综述强调了代谢重编程在 γ 疱疹病毒致癌中的关键作用及其对精准医学防治病毒驱动癌症的意义。
