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前胶原C蛋白酶增强蛋白通过激活ERK信号促进胶质瘤生长。

Procollagen C-protease enhancer protein promotes glioma growth by activating ERK signaling.

作者信息

Ma Zhenchao, Huang Daxing, Ru Lixin, Chen Ming

机构信息

Department of Radiation Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Department of Radiation Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, Huzhou, China.

出版信息

Asia Pac J Clin Oncol. 2025 Feb;21(1):48-57. doi: 10.1111/ajco.14127. Epub 2024 Oct 15.

DOI:10.1111/ajco.14127
PMID:39403870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11733849/
Abstract

BACKGROUND

Procollagen C-proteinase enhancer (PCOLCE) promotes tumor progression in multiple cancers. However, the specific role of PCOLCE in gliomas remains enigmatic. In this study, we focused on analyzing PCOLCE expression and its correlation with clinicopathological parameters in glioma specimens; moreover, we explored the effects of PCOLCE in glioma proliferation in vitro and in vivo.

METHODS

A tissue microarray containing 159 human glioma specimens was pressed to explore the correlation between PCOLCE expression and the survival of glioma patients. Cell Counting Kit-8 (CCK8), colony formation, and immunoblot assays were used to detect the role of PCOLCE on cell proliferation in glioma. Furthermore, the in vivo role of PCOLCE was investigated using a subcutaneous glioma xenograft model.

RESULTS

The expression of PCOLCE was higher in grade III and IV gliomas than in grade I and II gliomas. High PCOLCE expression was related to a remarkably worse prognosis in glioma patients. Additionally, PCOLCE downregulation impeded glioma cell proliferation. Furthermore, PCOLCE knockdown markedly abrogated p-ERK expression in glioma cells, whereas, it negligibly influenced p38 and JNK signaling.

CONCLUSIONS

These results indicate that PCOLCE is a feasible prognostic biomarker for glioma, and PCOLCE-induced activation of ERK signaling may be a pro-growth mechanism in glioma cells.

摘要

背景

前胶原C蛋白酶增强剂（PCOLCE）在多种癌症中促进肿瘤进展。然而，PCOLCE在胶质瘤中的具体作用仍不清楚。在本研究中，我们着重分析PCOLCE在胶质瘤标本中的表达及其与临床病理参数的相关性；此外，我们还探讨了PCOLCE在体外和体内对胶质瘤增殖的影响。

方法

压制一张包含159例人类胶质瘤标本的组织芯片，以探究PCOLCE表达与胶质瘤患者生存之间的相关性。使用细胞计数试剂盒-8（CCK8）、集落形成和免疫印迹分析来检测PCOLCE对胶质瘤细胞增殖的作用。此外，使用皮下胶质瘤异种移植模型研究PCOLCE在体内的作用。

结果

III级和IV级胶质瘤中PCOLCE的表达高于I级和II级胶质瘤。PCOLCE高表达与胶质瘤患者预后明显较差相关。此外，PCOLCE下调会阻碍胶质瘤细胞增殖。此外，PCOLCE敲低显著消除了胶质瘤细胞中p-ERK的表达，而对p38和JNK信号的影响可忽略不计。

结论

这些结果表明，PCOLCE是一种可行的胶质瘤预后生物标志物，PCOLCE诱导的ERK信号激活可能是胶质瘤细胞中的一种促生长机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/2004eb315847/AJCO-21-48-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/7a1cba6e5b00/AJCO-21-48-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/1d5ad6170b3c/AJCO-21-48-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/6db780cd15a8/AJCO-21-48-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/6f801298b229/AJCO-21-48-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/2004eb315847/AJCO-21-48-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/7a1cba6e5b00/AJCO-21-48-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/1d5ad6170b3c/AJCO-21-48-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/6db780cd15a8/AJCO-21-48-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/6f801298b229/AJCO-21-48-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d26e/11733849/2004eb315847/AJCO-21-48-g001.jpg

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