Shi Suming, Liu Xu, Li Wenquan, Wang Dan, Wang Wuqing
ENT Institute and Otorhinolaryngology Department, Affiliated Eye and ENT Hospital, Fudan University, Fenyang Road No.83, Shanghai, 200031, China.
NHC Key Laboratory of Hearing Medicine, Fudan University, Fenyang Road No.83, Shanghai, 200031, China.
Eur Arch Otorhinolaryngol. 2025 Mar;282(3):1231-1236. doi: 10.1007/s00405-024-09025-w. Epub 2024 Oct 15.
To investigate the clinical characteristics and endolymphatic hydrops (ELH) Manifestations in patients with delayed Ménière's disease (DMD) compared to classic Ménière's disease (CMD).
A prospective cohort study was conducted involving 523 patients diagnosed with MD. Clinical data, inner ear function, and ELH characteristics were analyzed and compared between CMD and DMD groups. Assessments included audiometry, VEMP, and MRI.
DMD prevalence was 6.1%. Bilateral MD was significantly more common in DMD (34.4% vs. 14.5%, P = 0.003). DMD patients had more severe hearing loss in the first involved ear and more deteriorated VEMP in the contralateral ear (P < 0.05). ELH was present in 100% of affected ears, with a higher contralateral ELH proportion in DMD (34.4% vs. 15.0%, P = 0.005).
DMD patients exhibit a higher prevalence of bilateral MD, more severe hearing loss, and greater contralateral ELH compared to CMD patients. Both subtypes share similar ELH characteristics, suggesting common underlying mechanisms.
探讨迟发性梅尼埃病（DMD）患者与经典梅尼埃病（CMD）患者相比的临床特征和内淋巴积水（ELH）表现。
进行了一项前瞻性队列研究，纳入523例被诊断为梅尼埃病的患者。分析并比较了CMD组和DMD组的临床数据、内耳功能及ELH特征。评估包括听力测定、前庭诱发肌源性电位（VEMP）和磁共振成像（MRI）。
DMD患病率为6.1%。双侧梅尼埃病在DMD中明显更为常见（34.4%对14.5%，P = 0.003）。DMD患者首次受累耳听力损失更严重，对侧耳VEMP恶化更明显（P < 0.05）。100%的患耳存在ELH，DMD中对侧ELH比例更高（34.4%对15.0%，P = 0.005）。
与CMD患者相比，DMD患者双侧梅尼埃病患病率更高、听力损失更严重且对侧ELH更明显。两种亚型具有相似的ELH特征，提示存在共同的潜在机制。
