Rundell Thomas B, Baranski Thomas J
Department of Biological Sciences, Binghamton University, Binghamton, NY, USA.
Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Adv Exp Med Biol. 2024 Oct 16. doi: 10.1007/5584_2024_827.
Disorders of lipid metabolism such as obesity have become some of the most significant diseases of the twenty-first century. Despite these metabolic diseases affecting more than a third of the population in highly industrialized nations, the mechanisms underlying disease development remain poorly understood. Insect models, such as Drosophila melanogaster, offer a means of systematically examining conserved lipid metabolism and its pathology. Over the past several decades, Drosophila melanogaster has been used to greatly expand on our knowledge of metabolic disease, often taking advantage of the extensive genetic tools available to researchers. Additionally, Drosophila melanogaster has served and will continue to serve as a powerful tool for validating the results of genome-wide approaches to the study of diseases. This chapter explores the advancements of insect models in the study of lipid metabolism disorders as well as highlight opportunities for future areas of research.
肥胖等脂质代谢紊乱已成为21世纪一些最为严重的疾病。尽管这些代谢性疾病在高度工业化国家影响着超过三分之一的人口，但疾病发展的潜在机制仍知之甚少。昆虫模型，如黑腹果蝇，提供了一种系统研究保守脂质代谢及其病理学的方法。在过去几十年里，黑腹果蝇被用于极大地扩展我们对代谢性疾病的认识，研究人员常常利用现有的丰富遗传工具。此外，黑腹果蝇已经并将继续作为一种强大工具，用于验证全基因组疾病研究方法的结果。本章探讨昆虫模型在脂质代谢紊乱研究方面的进展，并突出未来研究领域的机会。
