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当前和新兴的分子心血管成像放射性示踪剂。

Current and Emerging Radiotracers in Molecular Cardiovascular Imaging.

机构信息

BHF Centre for Cardiovascular Science, The University of Edinburgh, United Kingdom (S.S.J., J.G., D.E.N., M.R.D.).

Department of Cardiology, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Belgium (J.G.).

出版信息

Circ Cardiovasc Imaging. 2024 Oct;17(10):e016323. doi: 10.1161/CIRCIMAGING.123.016323. Epub 2024 Oct 15.

Abstract

Cardiovascular imaging has rapidly advanced over the past decades. Traditional imaging techniques such as echocardiography, computed tomography, and cardiovascular magnetic resonance are essential for assessing the structural and functional aspects of the cardiovascular system but often fall short in providing direct insights into disease activity. This gap is increasingly being bridged by molecular nuclear imaging techniques, including positron emission tomography and single-photon emission computed tomography, which enable the visualization of disease processes at the molecular and cellular levels. This review highlights the role of cardiovascular molecular imaging, emphasizing its current and potential applications in diagnosing and managing cardiovascular disease. With advancements in positron emission tomography scanners, novel radiotracers, and sophisticated imaging software, molecular imaging is set to play an essential role in precision medicine by enhancing our understanding of disease mechanisms, accelerating the development of targeted therapies, and facilitating personalized patient care.

摘要

心血管成像技术在过去几十年中迅速发展。传统的成像技术,如超声心动图、计算机断层扫描和心血管磁共振,对于评估心血管系统的结构和功能方面至关重要,但往往无法直接了解疾病的活动情况。这一差距正越来越多地被分子核成像技术所弥补,包括正电子发射断层扫描和单光子发射计算机断层扫描,这些技术能够在分子和细胞水平上可视化疾病过程。本综述强调了心血管分子成像的作用,重点介绍了其在诊断和管理心血管疾病方面的当前和潜在应用。随着正电子发射断层扫描仪、新型放射性示踪剂和复杂的成像软件的进步,分子成像有望通过增强我们对疾病机制的理解、加速靶向治疗的发展以及促进个性化患者护理,在精准医学中发挥重要作用。

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