Department of Archaeology, Durham University, South Road, Durham DH1 3LE, UK.
Wolfson Research Institute for Health and Wellbeing, Durham University, 42 Old Elvet, Durham DH1 3HN, UK.
Int J Paleopathol. 2024 Dec;47:27-42. doi: 10.1016/j.ijpp.2024.09.002. Epub 2024 Oct 14.
This study employs a Developmental Origins of Health and Disease (DOHaD) approach to assess the effect of vitamin D deficiency (VDD) in childhood on the risk of osteoporosis in adulthood in an archaeological sample of skeletons dating from the 18th to 19th centuries.
Femora and lumbar vertebrae of 65 adults aged 18+ years (26 diagnosed with residual rickets and 39 without) from an 18th-19th century Quaker burial ground at Coach Lane, North Shields, England.
Bone mineral density (BMD) was measured for the femoral neck and first four lumbar vertebrae of each individual using a dual energy X-ray absorptiometry (DXA) scanner as a proxy for assessing osteoporotic fracture risk.
3-way ANOVA revealed no statistically significant differences in BMD between individuals with and without residual rickets across age and sex.
A combination of lifestyle and environmental factors likely influenced the BMD of people buried at Coach Lane across the life course. The impact of childhood VDD on BMD later in life can be mitigated through other factors such as physical activity and diet.
This is one of the first bioarchaeological studies to take a DOHaD approach to understand osteoporosis risk in 18th-19th century England. It highlights the complexity of aetiological factors for osteoporosis and that VDD in early life does not necessarily predispose a person to osteoporosis in adulthood.
BMD is not the only indicator of osteoporosis. Microscopic methods for the assessment of childhood vitamin D deficiency, such as inter-globular dentine analysis, were not applied.
本研究采用健康与疾病的发育起源（DOHaD）方法，评估儿童期维生素 D 缺乏（VDD）对 18 至 19 世纪考古样本中成年人骨质疏松症风险的影响。
来自英格兰北希尔兹库奇巷 18 至 19 世纪贵格会墓地的 65 名 18 岁以上成年人（26 名被诊断为残余佝偻病，39 名无残余佝偻病）的股骨和腰椎。
使用双能 X 射线吸收仪（DXA）扫描仪测量每位个体的股骨颈和前四个腰椎的骨矿物质密度（BMD），作为评估骨质疏松性骨折风险的替代指标。
3 路方差分析显示，在年龄和性别方面，有无残余佝偻病的个体之间的 BMD 没有统计学上的显著差异。
生活方式和环境因素的综合作用可能影响了库奇巷墓地个体在整个生命过程中的 BMD。童年 VDD 对晚年 BMD 的影响可以通过其他因素（如体育活动和饮食）来减轻。
这是首次采用 DOHaD 方法研究 18 至 19 世纪英国骨质疏松症风险的生物考古研究之一。它强调了骨质疏松症病因因素的复杂性，并且儿童时期的 VDD 不一定会使人成年后易患骨质疏松症。
BMD 不是骨质疏松症的唯一指标。未应用评估儿童期维生素 D 缺乏的微观方法，如球间牙本质分析。
