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中世纪挪威某人群中的骨质疏松症

Osteoporosis in a population from medieval Norway.

作者信息

Mays S, Turner-Walker G, Syversen U

机构信息

Ancient Monuments Laboratory, English Heritage Centre for Archaeology, Eastney, Portsmouth PO4 9LD, UK.

出版信息

Am J Phys Anthropol. 2006 Nov;131(3):343-51. doi: 10.1002/ajpa.20445.

Abstract

Modern populations from Norway and England differ in their experience of osteoporosis, the former showing lower bone mineral density (BMD) and a higher fragility fracture rate. The aim of the present work was to investigate whether this was also the case during the Middle Ages. Age-dependent loss of BMD in the proximal femur was assessed using dual X-ray absorptiometry (DXA) in male and female adult skeletons from a cemetery in the medieval town of Trondheim, Norway. Fracture prevalence was also investigated. Results were compared with those previously reported for a skeletal series from Wharram Percy, a deserted medieval village in England. Results indicate that peak BMD and patterns of age-related loss of BMD in the Norwegian and the English group were similar. Among females, the prevalence of osteoporotic fractures was greater in the Norwegian than in the English population. The BMD results suggest that differences in BMD between English and Norwegians are of recent origin, although given the fairly modest sample sizes, further work is needed to confirm this. Reasons for the greater prevalence of osteoporotic fractures in women in the Norwegian skeletal series are unclear, but the colder climate and greater frequency of hard surfaces may have meant that falls were more frequent, and when they occurred, were more likely to result in fractures than in the rural English group.

摘要

来自挪威和英国的现代人群在骨质疏松症方面的情况有所不同,前者骨矿物质密度(BMD)较低,脆性骨折率较高。本研究的目的是调查在中世纪是否也是如此。使用双能X线吸收法(DXA)对挪威特隆赫姆中世纪城镇一座墓地中成年男女骨骼的股骨近端BMD随年龄的变化情况进行了评估。还对骨折患病率进行了调查。将结果与之前报道的来自英国废弃中世纪村庄惠勒姆·珀西的一组骨骼的数据进行了比较。结果表明,挪威组和英国组的峰值BMD以及与年龄相关的BMD丢失模式相似。在女性中,挪威人群骨质疏松性骨折的患病率高于英国人群。BMD结果表明,英国人和挪威人之间的BMD差异是近期出现的,不过鉴于样本量相当有限,还需要进一步研究来证实这一点。挪威骨骼样本中女性骨质疏松性骨折患病率较高的原因尚不清楚,但更寒冷的气候和更频繁的硬地面可能意味着摔倒更频繁,而且一旦摔倒,比起英国农村人群,更有可能导致骨折。

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