Department of Medical Biochemistry, Faculty of Medicine, Near East University, 99138, Lefkosa/ TRNC Mersin 10, Turkey.
Biochem Biophys Res Commun. 2024 Nov 26;735:150798. doi: 10.1016/j.bbrc.2024.150798. Epub 2024 Oct 10.
Despite their approval for inclusion in beverages, and food products, the safety of artificial sweeteners is still a topic of debate within the scientific community. A significant aspect of this debate focuses on the potential of artificial sweeteners to induce dysbiosis, an imbalance in the intestinal microbiota, which has been associated with many diseases including obesity, Type 2 diabetes, and cardiovascular diseases. The interactions and mechanisms of action of artificial sweeteners within the gut microbiota, as well as the extent of associated molecular alterations, are still under active investigation. This review aims to evaluate recent developments in artificial sweetener-induced dysbiosis with its associated molecular signatures. Importantly, potential future directions for research are proposed, offering insights that could guide further targeted studies and inform dietary recommendations and policy revisions.
尽管人工甜味剂已获准用于饮料和食品产品中，但在科学界，它们的安全性仍是一个争论的话题。这场争论的一个重要方面是关注人工甜味剂是否会引起肠道微生物失调，即肠道微生物群的失衡，这与许多疾病有关，包括肥胖、2 型糖尿病和心血管疾病。人工甜味剂在肠道微生物群中的相互作用和作用机制，以及相关分子变化的程度，仍在积极研究中。本综述旨在评估人工甜味剂诱导的肠道微生物失调及其相关分子特征的最新进展。重要的是，提出了潜在的未来研究方向，为进一步的靶向研究提供了见解，并为饮食建议和政策修订提供了信息。
