McComish Department of Electrical Engineering and Computer Science, Jerome J. Lohr College of Engineering, South Dakota State University, Brookings, SD, 57007, USA.
McComish Department of Electrical Engineering and Computer Science, Jerome J. Lohr College of Engineering, South Dakota State University, Brookings, SD, 57007, USA.
Biosens Bioelectron. 2025 Jan 1;267:116844. doi: 10.1016/j.bios.2024.116844. Epub 2024 Oct 9.
This review has explored optical sensors and their important role in non-invasive transdermal biomarker detection. While electrochemical sensors have been thoroughly studied for biomarker tracking, optical sensors present a compelling alternative due to their high sensitivity and selectivity, multiplex capabilities, cost-efficiency, and small form factor. This review examines the latest advancements in optical sensing technologies for transdermal biomarker detection, such as colorimetry, fluorescence, surface plasmon resonance (SPR), fiber optics, photonic crystals, and Raman spectroscopy. These technologies have been applied in the analysis of biomarkers present in sweat and skin gases, which are essential for non-invasive health monitoring. Furthermore, the review has discussed the challenges and future perspectives of optical sensors in in transdermal biomarker detection. The analysis of various sensor types and their applications highlights the transformative potential of optical sensors in enhancing disease diagnostics and promoting proactive health management.
本综述探讨了光学传感器及其在非侵入式透皮生物标志物检测中的重要作用。虽然电化学传感器已被深入研究用于生物标志物跟踪，但由于其高灵敏度和选择性、多重检测能力、成本效益和小尺寸等优势，光学传感器提供了一种极具吸引力的替代方案。本综述检查了用于透皮生物标志物检测的光学传感技术的最新进展，如比色法、荧光法、表面等离子体共振（SPR）、光纤、光子晶体和拉曼光谱法。这些技术已应用于分析汗液和皮肤气体中的生物标志物，这对于非侵入性健康监测至关重要。此外，本综述还讨论了光学传感器在透皮生物标志物检测中面临的挑战和未来展望。对各种传感器类型及其应用的分析突显了光学传感器在增强疾病诊断和促进主动健康管理方面的变革潜力。
