Biogem, Molecular Biology and Genetics Research Institute, Ariano Irpino, Italy.
Department of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Kidney Blood Press Res. 2024;49(1):884-897. doi: 10.1159/000541848. Epub 2024 Oct 15.
The potential applications of nanotechnology in the medical field have become increasingly recognized in recent years. Nanocarriers have emerged as a versatile tool, offering a wide range of applications due to their unique properties. In addition to the targeted drugs delivery, nanocarriers have also proven to be extremely effective in imaging and diagnostics. Continuous advances in nanotechnology have paved the way for innovative solutions to complex challenges in human health, shaping the future of nanotechnology and its applications.
By exploring different types of nanoparticles, this review delves into the different characteristics that can be tailored to enhance their kidney access. Although the structural complexity of the kidney may prevent nanocarriers passage, optimization of nanocarrier characteristics such as shape, size, charge, and surface modifications may overcome these barriers, allowing for targeted delivery. By harnessing the potential of nanoparticles, researchers aim to develop targeted and efficient therapies that can address various kidney-related disorders.
This review highlights the promising advancements in nanotechnology and their potential impact on improving the therapeutic outcomes for several kidney diseases.
近年来，纳米技术在医学领域的潜在应用越来越受到认可。纳米载体作为一种多功能工具，由于其独特的性质，具有广泛的应用。除了靶向药物传递外，纳米载体在成像和诊断方面也被证明非常有效。纳米技术的不断进步为解决人类健康复杂挑战提供了创新解决方案，塑造了纳米技术及其应用的未来。
通过探索不同类型的纳米粒子，本综述深入研究了可以针对增强其肾脏进入的不同特性。尽管肾脏的结构复杂性可能会阻止纳米载体的通过，但优化纳米载体的特性，如形状、大小、电荷和表面修饰，可以克服这些障碍，实现靶向递送。通过利用纳米粒子的潜力，研究人员旨在开发针对各种肾脏相关疾病的靶向和高效治疗方法。
本综述强调了纳米技术的有前景的进展及其对改善几种肾脏疾病治疗效果的潜在影响。
