Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul, 02707, Republic of Korea.
Department of Bio and Fermentation Convergence Technology, Kookmin University, Seoul, 02707, Republic of Korea.
Insect Biochem Mol Biol. 2024 Nov;174:104194. doi: 10.1016/j.ibmb.2024.104194. Epub 2024 Oct 13.
Chemical detection is vital for animal survival, aiding in avoiding toxins and selecting nutritious foods. While Drosophila larvae exhibit appetitive feeding behavior toward ribose, an important sugar for RNA, nucleotide, and nucleoside synthesis, how adult Drosophila perceives ribose remains unclear. Through behavioral and electrophysiological investigations, we unexpectedly discovered that adult flies actively avoid ribose. Our external electrophysiological analysis revealed that ribose is detected through bitter-sensing gustatory receptor neurons in S-type sensilla, suggesting its perception as a bitter compound. Additionally, we identify painless as crucial for both ribose aversion and the neuronal response to ribose.
化学检测对于动物的生存至关重要，有助于避免毒素和选择有营养的食物。虽然果蝇幼虫对核糖表现出食欲性的摄食行为，核糖是 RNA、核苷酸和核苷合成的重要糖，但成年果蝇如何感知核糖尚不清楚。通过行为和电生理研究，我们意外地发现成年果蝇主动回避核糖。我们的外部电生理分析表明，核糖是通过 S 型感器中的苦味感知味觉受体神经元来检测的，表明它被感知为一种苦味化合物。此外，我们发现无痛觉对于核糖的厌恶和对核糖的神经元反应都是至关重要的。
