Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Trends Pharmacol Sci. 2024 Nov;45(11):950-952. doi: 10.1016/j.tips.2024.09.010. Epub 2024 Oct 14.
Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.
线粒体钙摄取的调节由线粒体钙单向转运体（mtCU）复合物来完成，这对于心脏功能至关重要。在最近的一项研究中，Hasan 等人表明，复合物的调节亚基线粒体钙摄取（MICU）1 和 MICU2 有助于维持心脏线粒体中的钙稳态，为旨在改善心脏病中线粒体功能的治疗提供了潜在靶点。
