MICUs 通过调节线粒体钙来保护心脏。
MICUs protect the heart by regulating mitochondrial calcium.
机构信息
Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Department of Integrative Biology and Physiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
出版信息
Trends Pharmacol Sci. 2024 Nov;45(11):950-952. doi: 10.1016/j.tips.2024.09.010. Epub 2024 Oct 14.
Abstract
Regulation of mitochondrial calcium uptake by the mitochondrial calcium uniporter (mtCU) complex is crucial for heart function. In a recent study, Hasan et al. demonstrated that mitochondrial calcium uptake (MICU)1 and MICU2, regulatory subunits of the complex, help maintain calcium homeostasis in cardiac mitochondria, providing potential targets for therapies aimed at improving mitochondrial function in heart disease.
摘要
线粒体钙摄取的调节由线粒体钙单向转运体（mtCU）复合物来完成，这对于心脏功能至关重要。在最近的一项研究中，Hasan 等人表明，复合物的调节亚基线粒体钙摄取（MICU）1 和 MICU2 有助于维持心脏线粒体中的钙稳态，为旨在改善心脏病中线粒体功能的治疗提供了潜在靶点。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 2024 Aug 27;121(35):e2402491121. doi: 10.1073/pnas.2402491121. Epub 2024 Aug 20.
2
Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complex.组织特异性 MICU 调控线粒体钙单向转运体复合物的机制及意义。
Mol Cell. 2022 Oct 6;82(19):3661-3676.e8. doi: 10.1016/j.molcel.2022.09.006.
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The mechanism of MICU-dependent gating of the mitochondrial Cauniporter.MICU 依赖性线粒体钙单向转运体门控的机制。
Elife. 2021 Aug 31;10:e69312. doi: 10.7554/eLife.69312.
4
Structure of intact human MCU supercomplex with the auxiliary MICU subunits.完整的人类MCU超复合物与辅助MICU亚基的结构。
Protein Cell. 2021 Mar;12(3):220-229. doi: 10.1007/s13238-020-00776-w.
5
Structure and mechanism of the mitochondrial Ca uniporter holocomplex.线粒体钙单向转运体全复合物的结构与机制。
Nature. 2020 Jun;582(7810):129-133. doi: 10.1038/s41586-020-2309-6. Epub 2020 May 20.
6
Voltage-energized Calcium-sensitive ATP Production by Mitochondria.线粒体电压敏化钙敏感的 ATP 产生。
Nat Metab. 2019 Oct;1(10):975-984. doi: 10.1038/s42255-019-0126-8. Epub 2019 Oct 14.
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Improved mitochondrial stress response in long-lived Snell dwarf mice.长寿的斯内尔侏儒小鼠线粒体应激反应得到改善。
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