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Structure of intact human MCU supercomplex with the auxiliary MICU subunits.

作者信息

Zhuo Wei, Zhou Heng, Guo Runyu, Yi Jingbo, Zhang Laixing, Yu Lei, Sui Yinqiang, Zeng Wenwen, Wang Peiyi, Yang Maojun

机构信息

Ministry of Education Key Laboratory of Protein Science, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

Institute for Immunology and School of Medicine, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, China.

出版信息

Protein Cell. 2021 Mar;12(3):220-229. doi: 10.1007/s13238-020-00776-w.

DOI:10.1007/s13238-020-00776-w
PMID:32862359
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7895871/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35f/7895871/7b5380ffa8ac/13238_2020_776_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35f/7895871/f7ef19bdf546/13238_2020_776_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35f/7895871/7b5380ffa8ac/13238_2020_776_Fig2a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35f/7895871/f7ef19bdf546/13238_2020_776_Fig1a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c35f/7895871/7b5380ffa8ac/13238_2020_776_Fig2a_HTML.jpg

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本文引用的文献

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Structure and mechanism of the mitochondrial Ca uniporter holocomplex.线粒体钙单向转运体全复合物的结构与机制。
Nature. 2020 Jun;582(7810):129-133. doi: 10.1038/s41586-020-2309-6. Epub 2020 May 20.
2
Functional analysis of coiled-coil domains of MCU in mitochondrial calcium uptake.MCU 卷曲螺旋结构域在线粒体钙摄取中的功能分析。
Biochim Biophys Acta Bioenerg. 2019 Dec 1;1860(12):148061. doi: 10.1016/j.bbabio.2019.148061. Epub 2019 Aug 5.
3
Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter.
Trends Pharmacol Sci. 2024 Nov;45(11):950-952. doi: 10.1016/j.tips.2024.09.010. Epub 2024 Oct 14.
4
Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease.线粒体钙调节在心脏代谢中的作用：健康与疾病。
Physiology (Bethesda). 2024 Sep 1;39(5):0. doi: 10.1152/physiol.00014.2024. Epub 2024 May 7.
5
The MCU and MCUb amino-terminal domains tightly interact: mechanisms for low conductance assembly of the mitochondrial calcium uniporter complex.MCU和MCUb的氨基末端结构域紧密相互作用：线粒体钙单向转运体复合物低电导组装的机制。
iScience. 2024 Apr 10;27(5):109699. doi: 10.1016/j.isci.2024.109699. eCollection 2024 May 17.
6
The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases.心磷脂在线粒体功能和神经退行性疾病中的作用。
Cells. 2024 Mar 30;13(7):609. doi: 10.3390/cells13070609.
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An mutant line lacking the mitochondrial calcium transport regulator MICU shows an altered metabolite profile.一株缺乏线粒体钙转运调节剂 MICU 的突变株显示出代谢物图谱的改变。
Plant Signal Behav. 2023 Dec 31;18(1):2271799. doi: 10.1080/15592324.2023.2271799. Epub 2023 Oct 25.
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Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart.线粒体钙超载在心力衰竭中的氧化应激中起因果作用。
Biomolecules. 2023 Sep 19;13(9):1409. doi: 10.3390/biom13091409.
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Elife. 2019 Jan 15;8:e41112. doi: 10.7554/eLife.41112.
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