Ahn Emily, Shayo Aisa, Mselle Matei, Sechu Anna, Perlman Jeffrey
Division of Neonatology, NewYork-Presbyterian-Weill Cornell Medicine, New York, NY, USA.
Department of Pediatrics, Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
J Perinatol. 2025 Jan;45(1):63-67. doi: 10.1038/s41372-024-02153-5. Epub 2024 Oct 15.
To determine if a novel CPAP system is associated with physiologic improvement in premature infants in a low resource setting and if the introduction of blended oxygen would reduce FiO2.
Feasibility study of infants ≤2000 g or ≤32 weeks gestational age with early respiratory distress who were placed on Vayu CPAP with continuous pulse oximetry. Physiologic parameters were recorded prior to initiation and through the first 24 h.
Seventy-six infants of birthweight 1360 ± 324 g and gestational age 31.2 ± 2.5 weeks were included. Compared to baseline, heart rate, respiratory rate, FiO2, and Silverman Anderson score significantly decreased while oxygen saturations significantly increased at one hour with persistence through 24 h.
Utilization of Vayu CPAP in premature infants with respiratory distress was associated with immediate improvement in physiologic parameters. Use of blended oxygen coupled with pulse oximetry facilitates reduction in delivered oxygen.
确定一种新型持续气道正压通气（CPAP）系统在资源匮乏环境下是否与早产儿的生理状况改善相关，以及引入混合氧气是否会降低吸入氧浓度（FiO2）。
对出生体重≤2000g或胎龄≤32周且有早期呼吸窘迫的婴儿进行可行性研究，这些婴儿接受Vayu CPAP并持续进行脉搏血氧饱和度监测。在开始治疗前及治疗后的头24小时记录生理参数。
纳入了76名出生体重为1360±324g、胎龄为31.2±2.5周的婴儿。与基线相比，心率、呼吸频率、FiO2和西尔弗曼-安德森评分显著降低，而血氧饱和度在1小时时显著升高，并持续至24小时。
在有呼吸窘迫的早产儿中使用Vayu CPAP与生理参数的立即改善相关。混合氧气与脉搏血氧饱和度监测相结合有助于降低输送的氧气量。
